Opakalim (BHV-7000) Potentiates the Activity of Kv7.2/7.3 Channels Containing a Single Copy of the Kv7.2 DEE-Causing Mutation, G281E (P3-10.009)

Key Result

Opakalim (BHV-7000) potentiates the in vitro activity of Kv7.2/7.3 channels containing a single copy of the Kv7.2 DEE-causing mutation G281E.

Key Points

• This study aims to evaluate the effect of opakalim on Kv7.2/7.3 channels containing a specific mutation associated with developmental and epileptic encephalopathy.
• In vitro assessment of Kv7.2/7.3 channel activity using opakalim (BHV-7000) in the presence of a DEE-causing mutation.
• Focused on channels featuring the G281E mutation to determine the efficacy of the activator.
• Opakalim significantly potentiates the activity of Kv7.2/7.3 channels with the G281E mutation, enhancing channel function compared to controls.