Small Vessel and Glymphatic Dysfunction In Asymptomatic Intracranial Atherosclerosis Relates to Cognition and Predicts Decline (P3-4.020) | Synapse
June 13, 2026
Small Vessel and Glymphatic Dysfunction In Asymptomatic Intracranial Atherosclerosis Relates to Cognition and Predicts Decline (P3-4.020)
Key Points
This research aims to explore the relationship between imaging indicators of small-vessel and glymphatic dysfunction with cognitive function in asymptomatic intracranial atherosclerosis.
Utilized imaging biomarkers to assess small-vessel and glymphatic dysfunction.
Analyzed cognitive performance in participants with asymptomatic intracranial atherosclerotic stenosis.
Investigated the predictive value of dysfunction biomarkers for cognitive decline.
Identified significant correlation between small-vessel dysfunction and cognitive performance.
Glymphatic dysfunction markers showed predictive value for subsequent cognitive decline.
Results indicate a potential avenue for early intervention strategies in asymptomatic aICAS.
Abstract
Test whether imaging indicators of small-vessel and glymphatic dysfunction biomarkers relate to cognition in asymptomatic intracranial atherosclerotic stenosis (aICAS) and predict subsequent decline.