Reversible phosphorylation of myosin and myosin kinase is the major regulatory mechanism controlling the interaction of actin and myosin in vertebrate smooth-muscle and non-muscle cells.
This review details the biochemical mechanisms of actin-myosin interaction regulation via phosphorylation in smooth and non-muscle cells.
In this paper we deal with the regulation of contractile activity in vertebrate smooth-muscle and non-muscle cells. In particular, we focus on what is thought to be the major regulatory mechanism controlling the interaction of actin and myosin in these cells: the reversible phosphorylation of myosin and the enzyme myosin kinase (for review, see Adelstein and Eisenberg 1980; Hartshorne and Gorecka 1980).
Adelstein et al. (1982) conducted a review in Regulation of contractile activity in vertebrate smooth-muscle and non-muscle cells. Reversible phosphorylation of myosin and myosin kinase was evaluated on Interaction of actin and myosin. Reversible phosphorylation of myosin and myosin kinase is the major regulatory mechanism controlling the interaction of actin and myosin in vertebrate smooth-muscle and non-muscle cells.