ANF mRNA is localized predominantly in the adrenal medulla, while ANF binding sites are concentrated in the adrenal cortex, suggesting medullary ANF may regulate cortical steroid secretion.
The factor inhibiting aldosterone secretion produced by the adrenal medulla may be atrial natriuretic factor (ANF), since the latter abolishes aldosterone release in response to a number of secretagogues, including angiotensin II and K+. In this study we have shown that cells in the adrenal medulla contain ANF mRNA and therefore have the potential to synthesize this peptide. The presence of binding sites for ANF predominantly in the adrenal zona glomerulosa suggests that, if ANF is synthesized in the medulla and transferred to the cortex, it may affect mineralocorticoid status.
Nunez et al. (Mon,) reported a other. Tissue analysis for ANF mRNA and binding sites was evaluated on Localization of ANF mRNA and binding sites. ANF mRNA is localized predominantly in the adrenal medulla, while ANF binding sites are concentrated in the adrenal cortex, suggesting medullary ANF may regulate cortical steroid secretion.
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