Key points are not available for this paper at this time.
A general approach to 3-azabicyclo3.1.1heptanes by reduction of spirocyclic oxetanyl nitriles was developed. The mechanism, scope, and scalability of this transformation were studied. The core was incorporated into the structure of the antihistamine drug Rupatidine instead of the pyridine ring, which led to a dramatic improvement in physicochemical properties.
Dibchak et al. (2023) studied this question.