Modulating hyperpolarization‐activated cyclic nucleotide‐gated channels for neuropathic pain

Key Points

• The aim is to explore how modulating hyperpolarization-activated cyclic nucleotide-gated channels can affect neuropathic pain.
• Investigated various modulation techniques on hyperpolarization-activated cyclic nucleotide-gated channels.
• Utilized preclinical models to assess the impact on neuropathic pain symptoms.
• Modulation of these channels significantly reduced neuropathic pain symptoms.
• Enhanced functionality of channels resulted in decreased pain sensitivity in preclinical models.