Circulating miR-29a-3p, miR-185-5p, and miR-454-3p were overexpressed in HCM, ACM, and DCM respectively, though consistent correlations with cardiac features were not detected.
Systematic Review
Do circulating microRNAs serve as accurate non-invasive diagnostic biomarkers for hypertrophic, arrhythmogenic, and dilated cardiomyopathies compared to healthy controls?
Specific circulating miRNAs are overexpressed in structural cardiomyopathies, but current evidence lacks consistency and requires validation in larger, standardized cohorts before clinical use.
Abstract Hypertrophic cardiomyopathy (HCM), arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy (DCM) represent the most frequent structural heart disorders. Due to the complexity of their diagnosis and the frequent occurrence of sudden cardiac death as the first manifestation, these diseases impose a relevant socio-economic burden, highlighting the urgent need for novel disease-specific biomarkers. Here, we assess the potential of microRNAs (miRNAs) as non-invasive predictors for HCM, ACM, and DCM. Electronic databases were systematically searched using relevant keywords pertaining to the disorders and miRNAs. To minimize spurious associations, only studies reporting the area under the curve (AUC) and including healthy controls were taken into account, resulting in the selection of 19 papers for further analyses. miR-29a-3p, miR-185-5p, and miR-454-3p were found overexpressed in HCM, ACM, and DCM, respectively, across different studies. Assessment of the correlation between circulating miRNA levels and cardiac features or genetic background failed to detect consistent profiles among different studies. Thus, further investigations employing consistent approaches and larger cohorts are required to validate the clinical utility of circulating miRNAs as non-invasive biomarkers for these structural cardiomyopathies. Systematic review registration PROSPERO CRD42023330236.
Léger et al. (Fri,) conducted a systematic review in Hypertrophic cardiomyopathy, arrhythmogenic cardiomyopathy, and dilated cardiomyopathy. Circulating microRNAs vs. Healthy controls was evaluated on Diagnostic accuracy (AUC) of circulating miRNAs. Circulating miR-29a-3p, miR-185-5p, and miR-454-3p were overexpressed in HCM, ACM, and DCM respectively, though consistent correlations with cardiac features were not detected.
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