Cancer patients have a higher risk of atrial fibrillation, and managing their anticoagulation requires individualized assessment due to unvalidated risk scores and complex drug interactions.
This review highlights the complex pathophysiology of AF in cancer patients and emphasizes the need for individualized anticoagulation strategies due to unique bleeding risks and drug-drug interactions.
Cancer patients have a higher risk of atrial fibrillation (AF) than general population, the pathophysiology mechanisms involves the pro inflammatory status of immune system in these patients and the exacerbated inflammatory response to cancer treatment and surgeries. Adequate management and prophylaxis for its occurrence are important and reduce morbidity and mortality in this population. There is a challenge in AF related to cancer to predict thromboembolic and bleeding risk in these patients, once standard stroke and hemorrhagic prediction scores are not validated for them. It is used CHA2DS2-VASc and HAS-BLED scores, the same as used in general population. In this review, we demonstrate correlated mechanisms to occurrence AF in cancer patients as well as therapeutic challenges in this population.
Hajjar et al. (Thu,) conducted a review in Atrial Fibrillation and Cancer. Anticoagulation and antiarrhythmic therapy was evaluated. Cancer patients have a higher risk of atrial fibrillation, and managing their anticoagulation requires individualized assessment due to unvalidated risk scores and complex drug interactions.