Lower circulating hepcidin concentration (OR 0.29 per log ng/ml) and hyperferritinemia (OR 2.05) were independently associated with high aortic stiffness in patients with essential hypertension.
Cross-Sectional (n=568)
No
Are circulating hepcidin, ferritin, and hemochromatosis gene mutations associated with arterial stiffness in patients with essential hypertension?
In patients with essential hypertension, hyperferritinemia and low circulating hepcidin are associated with increased aortic stiffness and cardiac diastolic dysfunction.
Odds Ratio: 0.29 (95% CI 0.16–0.51)
p-value: p=<0.001
BACKGROUND p=0.022), and lower circulating hepcidin concentration (OR 0.29, 95% c.i. 0.16-0.51 per log ng/ml; p<0.001). In subgroup analyses, high PWV was associated with indices of target organ damage, including micro-albuminuria (n=125, p=0.038), lower ejection fraction (n=175, p=0.031), cardiac diastolic dysfunction (p=0.004), and lower S wave peak systolic velocity (p<0.001). Ferritin was associated with cardiac diastolic dysfunction, independently of confounders (p=0.006). CONCLUSIONS: In conclusion, hyperferritinemia is associated with high aortic stiffness and cardiac diastolic dysfunction, while low circulating hepcidin with high aortic stiffness.
Valenti et al. (Wed,) conducted a cross-sectional in Essential hypertension (n=568). Circulating hepcidin and hyperferritinemia vs. Lower hepcidin / normal ferritin levels was evaluated on High aortic stiffness (upper tertile of carotid-femoral pulse wave velocity) (OR 0.29, 95% CI 0.16-0.51, p=<0.001). Lower circulating hepcidin concentration (OR 0.29 per log ng/ml) and hyperferritinemia (OR 2.05) were independently associated with high aortic stiffness in patients with essential hypertension.