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Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. Denk et al. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8 + T cells, resulting in generation regenerative stem cell-like memory (T SCM ) cells with enhanced antitumor properties.
Denk et al. (Tue,) studied this question.