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January 19, 2015Expert Review of Vaccines72 citations

Polio endgame: the global introduction of inactivated polio vaccine

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MPManish PatelSZSimona ZipurskyWOWalt Orenstein

Structured PICO

P
Population
126 OPV-only using countries globally
I
Intervention
Introduction of at least one dose of inactivated polio vaccine into routine immunization programs before the trivalent OPV-bivalent OPV switch
O
Outcome
Reduction of risks of reintroduction of type 2 poliovirus, facilitation of interruption of transmission, and acceleration of eradication

The introduction of inactivated polio vaccine is recommended globally to mitigate risks associated with immunity gaps following the phased withdrawal of oral polio vaccines.

Abstract

In 2013, the World Health Assembly endorsed a plan that calls for the ultimate withdrawal of oral polio vaccines (OPV) from all immunization programs globally. The withdrawal would begin in a phased manner with removal of the type 2 component of OPV in 2016 through a global switch from trivalent OPV to bivalent OPV (containing only types 1 and 3). To mitigate risks associated with immunity gaps after OPV type 2 withdrawal, the WHO Strategic Advisory Group of Experts has recommended that all 126 OPV-only using countries introduce at least one dose of inactivated polio vaccine into routine immunization programs by end-2015, before the trivalent OPV-bivalent OPV switch. The introduction of inactivated polio vaccine would reduce risks of reintroduction of type 2 poliovirus by providing some level of seroprotection, facilitating interruption of transmission if outbreaks occur, and accelerating eradication by boosting immunity to types 1 and 3 polioviruses.

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Cite This Study

Patel et al. (2015) studied this question.

synapsesocial.com/papers/6a70d6898031ec7bb1dc9d38https://doi.org/10.1586/14760584.2015.1001750
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