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April 1, 1989The Journal of Experimental Medicine73 citationsOpen Access

Human monocytes can produce tissue-type plasminogen activator.

PHPrue H. HartGVGerard F. VittiDBD R Burgess

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Abstract

Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.

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Cite This Study

Hart et al. (1989) studied this question.

synapsesocial.com/papers/6a70e8692163a0a01bc51bf4https://doi.org/10.1084/jem.169.4.1509
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