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July 22, 2022International Journal of Health Sciences0 citationsOpen Access

cross sectional observational study of cardiovascular response after propofol and etomidate anaesthesia induction

SKSachin KumbhareYTYogesh TilkarRCRitesh Churihar

Key Result

Etomidate induction resulted in significantly more stable hemodynamics, including higher systolic blood pressure after induction compared to propofol (107.4 vs 95.1 mmHg, p<0.001).

Study Design

Type

Cross-Sectional (n=95)

Structured PICO

Does etomidate improve hemodynamic stability compared to propofol during induction of general anaesthesia in elective surgery patients?

P
Population
95 ASA grade I and II adults aged 18-60 years undergoing elective surgery requiring general anesthesia and endotracheal intubation, monitored for 10 minutes post-induction.
E
Exposure
Etomidate 0.3 mg/kg intravenous injection for anaesthesia induction
C
Comparator
Propofol 1% 2 mg/kg intravenous injection for anaesthesia induction
O
Outcome
Cardiovascular response (systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, and O2 saturation) measured prior to induction, after induction, and at 1, 3, 5, and 10 minutes following laryngoscopysurrogate

Etomidate provides better hemodynamic stability compared to propofol during the induction of general anaesthesia in elective surgeries.

Main Result

Absolute Event Rate: 107.4% vs 95.1%

p-value: p=<0.001

Abstract

Etomidate and propofol are two common anaesthetic drugs. Etomidate can be used in patients with little hemodynamic reserve, whereas Propofol can result in more hemodynamic instability, according to prior research. During the induction of anaesthesia with Etomidate or, as a comparison, Propofol in elective surgeries, the cardiovascular response was examined in this study. Patients who were admitted for elective surgeries and ranged in age from 18 to 60 were included in this cross-sectional observational study. The cardiovascular responses of 50 (47) patients were assessed prior to induction, after the induction of anaesthesia with drugs, and at 1, 3, 5, and 10 minutes following the laryngoscopy. These measurements included systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and O2 saturation (O2 sat). In terms of patient gender, age, and weight, there were no statistically significant differences between the two groups. At different times, changes in groups I and II's SBP, DBP, MAP, and HR were statistically significant. There were no discernible differences between groups I and II in terms of O2 saturation. Conclusion: Because Etomidate-treated patients have improved hemodynamic stability, it may be preferable to Propofol for general anaesthesia in the absence of contraindications.

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Cite This Study

Kumbhare et al. (2022) conducted a cross-sectional in Elective surgery requiring general anesthesia (n=95). Etomidate vs. Propofol (2 mg/kg) was evaluated on Systolic blood pressure (SBP) after induction (p=<0.001). Etomidate induction resulted in significantly more stable hemodynamics, including higher systolic blood pressure after induction compared to propofol (107.4 vs 95.1 mmHg, p<0.001).

synapsesocial.com/papers/6a84732b121b098de683f009https://doi.org/10.53730/ijhs.v6ns6.10974
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