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August 23, 2026Cancers0 citationsOpen Access

Artificial Intelligence for Diagnostic and Prognostic Support in Breast Cancer: A Literature Overview

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DPDiana Gina PoalelungiANAnca‐Iulia NeaguAFAna Fulga

Key Points

  • To review the current landscape of machine learning and deep learning applications for breast cancer diagnosis, prognosis, and therapeutic decision-making in pathology workflows.
  • Synthesized literature on deep learning and machine learning algorithms designed for digital breast pathology.
  • Evaluated platform utility across tumor detection, histological grading, biomarker quantitation, and treatment response forecasting.
  • Analyzed the clinical validation levels, regulatory approvals, routine workflow integration, and primary implementation challenges.
  • AI models demonstrate high clinical potential for automating tumor identification, classifying tissue histology, and quantifying predictive biomarkers.
  • Decision-support algorithms show emerging capabilities in predicting therapeutic responsiveness and prognostic outcomes in breast oncology.
  • Widespread clinical integration remains hindered by gaps in external validation, regulatory clearance, and seamless laboratory workflow adoption.

Abstract

Artificial intelligence (AI) is increasingly being integrated into medical practice, offering promising tools to improve diagnostic accuracy and clinical efficiency. In the field of breast pathology, AI applications, particularly those based on deep learning (DL) and machine learning (ML), are emerging as decision-support tools in both diagnostic and prognostic workflows. This review provides a comprehensive overview of current AI-based approaches, with a focus on their clinical utility in tumor detection, histological classification, biomarker assessment, and prediction of treatment response. In addition to summarizing available AI platforms, the review critically examines their level of clinical validation, regulatory status, and integration into routine practice. Key challenges are also discussed. Overall, AI is expected to play an increasingly important role in supporting pathologists and advancing precision medicine in breast cancer management.

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Cite This Study

Poalelungi et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadf37677a3411444681dhttps://doi.org/10.3390/cancers18162723
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