High trough plasma concentrations of rivaroxaban (>200 ng/mL) were associated with a 2.8-fold higher odds of developing renal impairment compared to low concentrations (<50 ng/mL) in elderly patients.
Observational (n=100)
No
Do higher rivaroxaban plasma concentrations increase the risk of renal impairment in elderly patients?
Higher trough plasma concentrations of rivaroxaban are significantly associated with an increased risk of renal impairment in elderly patients, suggesting a potential benefit for therapeutic drug monitoring in this vulnerable population.
Odds Ratio: 2.8 (95% CI 1.3–6)
Absolute Event Rate: 60% vs 20%
p-value: p=0.009
Background: Rivaroxaban is a widely used anticoagulant, but its impact on renal function, particularly at varying plasma concentrations, remains a critical area of investigation. This study examines the relationship between rivaroxaban concentration and renal impairment in elderly patients. Aims and Objectives: The aim of the study was to investigate the relationship between rivaroxaban plasma concentrations and the incidence of renal impairment in elderly patients. Materials and Methods: A retrospective observational study was conducted on 100 elderly patients prescribed rivaroxaban for atrial fibrillation or venous thromboembolism prevention. Patients were categorized based on their rivaroxaban plasma concentrations into three groups: Low (200 ng/mL). Renal impairment was characterized as having an estimated glomerular filtration rate <60 mL/min/1.73 m². The analysis of the data consisted of Chi-square testing and multivariable logistic regression, with adjustments made for age, gender, baseline renal function, and treatment indication. Results: The incidence of renal impairment escalated with increasing rivaroxaban concentrations, 20%, 40%, and 60% in low, medium, and high concentration groups, respectively. Statistical analysis revealed a significant association between rivaroxaban concentration and renal impairment (χ2=10.57, P=0.005). Patients with high concentrations had 2.8-fold higher odds of developing renal impairment compared to the low concentration group. Cox proportional hazards analysis showed a 2.2 times higher hazard of renal impairment in high versus low concentration groups over 18 months. Conclusion: Higher trough plasma concentrations of rivaroxaban are associated with an increased risk of renal impairment in elderly patients. This finding highlights the importance of monitoring rivaroxaban levels to mitigate renal risks.
Rani et al. (2024) conducted an observational in Atrial fibrillation or venous thromboembolism prevention (n=100). High rivaroxaban plasma concentration (>200 ng/mL) vs. Low rivaroxaban plasma concentration (<50 ng/mL) was evaluated on Incidence of renal impairment (eGFR <60 mL/min/1.73 m²) (OR 2.8, 95% CI 1.3-6.0, p=0.009). High trough plasma concentrations of rivaroxaban (>200 ng/mL) were associated with a 2.8-fold higher odds of developing renal impairment compared to low concentrations (<50 ng/mL) in elderly patients.