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April 1, 1967Circulation34 citations

Early Results of Use of Homografts for Replacement of the Aortic Valve in Man

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THT. D. HoeksemaMayo ClinicJTJack L. TitusRegions HospitalEGEmilio R. GiulianiUniversity of Minnesota

Key Result

Insertion of an aortic valvular homograft in 50 patients resulted in a 6% hospital mortality rate, with no thromboembolic complications and 1 case of significant incompetence at 3 to 12 months.

Study Design

Type

Observational (n=50)

Multicenter

No

PICO

P
Population
50 patients undergoing insertion of an aortic valvular homograft after excision of the aortic valve at the Mayo Clinic, followed for 3 to 12 months.
E
Exposure / Comparator
Aortic valvular homograft
O
Primary Outcome
Hospital mortality rate

Abstract

The first 50 cases at the Mayo Clinic of insertion of an aortic valvular homograft after excision of the aortic valve are reported. The hospital mortality rate was 6%. An aortic diastolic murmur was noted in 17% of the surviving patients just prior to their dismissal from the hospital. In none was there evidence of hemodynamically significant aortic valvular incompetence. At follow-up examination 3 to 12 months postoperatively, an aortic diastolic murmur was audible in 44% of the traced patients. Only one patient had hemodynamically significant aortic valvular incompetence. The patients were not given anticoagulant therapy, and there were no thromboembolic complications.

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Cite This Study

Hoeksema et al. (1967) conducted an observational in Aortic valve disease (n=50). Aortic valvular homograft was evaluated on Hospital mortality rate. Insertion of an aortic valvular homograft in 50 patients resulted in a 6% hospital mortality rate, with no thromboembolic complications and 1 case of significant incompetence at 3 to 12 months.

synapsesocial.com/papers/6a934358f818c7d87e06a851https://doi.org/10.1161/01.cir.35.4s1.i-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of Aortic Valve Homografts for Aortic Valve Replacement1971 · 29 citations
  2. 2Early Clinical Experience with Homotransplantation of the Aortic Valve1967 · 16 citations
  3. 3Homograft Replacement of the Mitral Valve1968 · 17 citations
  4. 4Aortic Homograft Valve Replacement1969 · 115 citations
  5. 5Aortic valve and/or aortic root replacement using an aortic homograft2009 · 4 citations