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December 23, 2009Histopathology121 citations

Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases

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DMDaniela MassiAFAlessandro FranchiLALlúcia Alós

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Abstract

Massi D, Franchi A, Alos L, Cook M, Di Palma S, Enguita A B, Ferrara G, Kazakov D V, Mentzel T, Michal M, Panelos J, Rodriguez‐Peralto J L, Santucci M, Tragni G, Zioga A most tumours showed a fasciculated ( n = 23), pilar‐type ( n = 12) and pleomorphic ( n = 1) pattern. During the follow‐up period (range 2–192, mean 41 months) recurrences occurred in 1/16 (6.2%) of tumours confined to the dermis and in 2/11 (18.1%) tumours with minimal subcutis extension. The three recurrent tumours were high‐grade LMS, two of which exhibited myxoid areas. One patient with a pleomorphic dermal LMS with minimal extension into fat developed distant metastases 15 years after diagnosis. Conclusions : For LMS involving the skin, it is advisable to recognize and indicate in the histopathology report the depth of dermal and/or subcutaneous extension, since even minimal subcutaneous involvement may be associated with late local recurrences and/or distant metastases, and therefore appropriate and long‐term follow‐up is needed.

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Massi et al. (2009) studied this question.

synapsesocial.com/papers/6a93a16f63707cae7872123ehttps://doi.org/10.1111/j.1365-2559.2009.03471.x
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