Large-vessel disease was associated with a higher mean common carotid artery intima-media thickness compared to small-vessel disease (adjusted mean difference 0.11 mm; 95% CI 0.05-0.18).
Observational (n=532)
Is common carotid artery intima-media thickness different between patients with large-vessel and small-vessel ischemic stroke?
Common carotid artery intima-media thickness is significantly higher in large-vessel compared to small-vessel ischemic stroke, supporting different underlying pathogeneses.
Mean Difference: 0.11 (95% CI 0.05–0.18)
Absolute Event Rate: 1.08% vs 0.92%
BACKGROUND AND PURPOSE: The role of athersclerosis in the difference between the pathogenesis of large-vessel disease (LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patients. METHODS: Two independent observers classified ischemic stroke or transient ischemic attack as caused by SVD or LVD, primarily based on imaging and in addition on clinical features. Mean CCA IMT was calculated based on 6 measurements for each patient. RESULTS: Four hundred and seventeen patients were classified LVD and 115 SVD. Mean CCA IMT was higher in patients with LVD (1.08 mm) than in patients with SVD (0.92 mm). The crude mean difference was 0.16 mm (95% CI, 0.09 to 0.23). After adjustment for age, sex and hypertension, the mean difference was 0.11 mm (95% CI, 0.05 to 0.18). CONCLUSIONS: CCA IMT is higher in LVD patients than in SVD patients supporting the hypothesis that LVD and SVD have a different pathogenesis.
Pruissen et al. (2007) conducted an observational in Ischemic stroke or transient ischemic attack (n=532). Large-vessel disease vs. Small-vessel disease was evaluated on Mean common carotid artery intima-media thickness (CCA IMT) (Adjusted MD 0.11 mm, 95% CI 0.05 to 0.18). Large-vessel disease was associated with a higher mean common carotid artery intima-media thickness compared to small-vessel disease (adjusted mean difference 0.11 mm; 95% CI 0.05-0.18).