Krembil Research Institute

Recent papers from Krembil Research Institute

1. Dipyridamole analogs uncouple two dipyridamole activities: induction of cancer cell death and inhibition of platelet aggregationCell Death and Disease · 2026
2. Canadian Spine SocietyLongitudinal changes in comprehensive radiographic parameters following short-segment surgery (1–2 levels) for degenerative lumbar spondylolisthesisMeasuring spinopelvic parameters in patients with 6 lumbar vertebrae: a matched comparison of asymptomatic volunteersSupervised and unsupervised machine learning reveals distinct clinical phenotypes across degenerative lumbar conditions: sex-specific clustering for personalized surgical careDoes disc degeneration matter? Outcomes of decompression-alone surgery in low-grade spondylolisthesisIntervertebral disc degeneration in humans: altered peripheral immune cell profile in patients and inflammation-mediated matrix metalloproteinase upregulation in human disc cellsDomino toppling: when the disruption of one disc negatively impacts its neighbour. An investigation into the mechanism of adjacent segment diseaseMultimodal analgesia after surgery for thoracolumbar spinal stenosisLumbar foraminal morphology can affect outcomes of indirect decompression: a novel classificationPredictors of intraoperative vascular complications during anterior lumbar spinal exposure: a retrospective analysisHigher rates of fusion with porous titanium than with polyetheretherketone (PEEK) lumbar interbody cages: a retrospective cohort studyCan measuring preoperative postvoid urine residual values influence care in patients undergoing elective spine surgery?To respond or not to respond: the many faces of recovery after lumbar spine surgeryPostoperative outcomes in primary versus revision lumbar decompressive surgery: a propensity-matched analysisWhat are the barriers and enablers influencing physical activity among patients awaiting spine surgery? A qualitative study guided by the Theoretical Domains FrameworkEffects of childbearing on spinopelvic alignmentClinical and radiological outcomes of biportal endoscopic lumbar interbody fusion using oblique lateral interbody fusion-type cage: preliminary results and learning curve analysisArtificial intelligence for spine surgery education: a comparative analysis of ChatGPT and DeepSeek performanceSpineNavigator: a surgeon-trained large language model to enhance communication and patient education in spine surgeryDoes comorbidity count, ASA score, or Quan-modified Charlson Comorbidity Index score better predict morbidity after elective spinal surgery?Factors associated with perioperative adverse events in patients with degenerative lumbar spondylolisthesisImplementation of an awake spine surgery program in Canada: lessons learned from the surgeon’s perspectiveLongitudinal finite mixture models for mining complex prognostic phenotypes of degenerative cervical myelopathyEnvironmental impacts of a cervical laminectomy and fusion procedure from first consultation to patient recovery: insights from a life cycle assessmentReframing mild degenerative cervical myelopathy: insights from a latent profile analysisPredictive algorithm for treatment recommendation between operative and nonoperative management in mild degenerative cervical myelopathyMachine learning classification of patients with degenerative cervical myelopathy into clinically relevant clusters and development of an adoptable clinical algorithmReassessing the minimal clinically important differences of patient-reported outcomes in cervical myelopathy: a patient-centred approach from the Canadian Spine Outcomes and Research NetworkCurrent practices in return-to-play recommendations for recreational athletes following cervical spine surgeries: a preliminary global surveyCage subsidence and fusion in ACDF, a comparison between autograft, allograft, and synthetic cagesQuantifying cervical cord deformation with automated MRI: validation and clinical correlates in degenerative cervical myelopathyThe impact of estrogen replacement therapy on revision rates and outcomes after anterior cervical discectomy and fusion: a propensity-matched cohort studyImaging biomarkers derived using artificial intelligence pipeline–enhanced prognostication of patients undergoing surgery for nontraumatic spinal cord injury due to degenerative cervical myelopathyWhat patients expect and what they experience: symptom-specific expectation fulfillment and functional recovery in degenerative cervical myelopathy. A retrospective analysis of prospectively collected data from the multicentre Canadian Surgical Spine RegistryBiomechanical comparison of 7 occipital–cervical fixation constructs using finite element analysisOutpatient anterior cervical decompression and fusion: a survey of Canadian surgeonsNational trends in surgical approach for degenerative cervical myelopathy and associated inpatient costsVariability of mechanism of mechanical complications between low-thoracic to pelvis and lumbar to pelvis fusions accurately predicted by musculoskeletal analysisOutcomes of circumferential minimally invasive technique versus open technique in adult spinal deformity surgery patients over 80 years of age: aCanadian Journal of Surgery · 2026
3. Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding successNature Neuroscience · 2026
4. Longitudinal Cognitive and Affective Outcomes Following Unilateral MR-Guided Focused Ultrasound Vim Thalamotomy in Essential Tremor and Parkinson’s Disease: A Real-World CohortBiomedicines · 2026
5. Associations Between Clinical Characteristics and Magnetic Resonance Imaging of the Sacroiliac Joints and Spine: Exploratory Analysis of the Phase 4, Randomized, Placebo-Controlled STAR StudyJournal of Psoriasis and Psoriatic Arthritis · 2026
6. Responsiveness of patient-reported outcomes by disease trajectory in systemic lupus erythematosusLara D. Veeken · 2026
7. Antimalarial exposure and renal histopathologic findings in lupus nephritisLara D. Veeken · 2026
8. Short- and Long-Term Outcomes After MAIA-Guided Biofeedback Training in 346 Patients with Low Vision: A Retrospective Cohort StudyBrain Sciences · 2026
9. Targeted treatments for brain arteriovenous malformations: a reviewActa Neurochirurgica · 2026
10. Rethinking the role of animal models in adaptive deep brain stimulation: From feasibility to mechanistic and disease-modifying insightsNeuroscience & Biobehavioral Reviews · 2026
11. Mental Health Recovery Trajectories After Surgery for Degenerative Cervical MyelopathySpine · 2026
12. Clinical Improvement, No Improvement, and Worsening at 24 Hours Following Reperfusion in Patients With Stroke due to Large-Vessel OcclusionStroke Vascular and Interventional Neurology · 2026
13. Head-only MRI of deep brain stimulation devices at 0.5 T: Patient-derived approaches for estimating radiofrequency heatingNeuroImage · 2026
14. Biallelic Pathogenic Variants in PYGM Impair Retinal Glycogenolysis Causing a Range of PhenotypesInvestigative Ophthalmology & Visual Science · 2026
15. Occupational Vulnerability to AI‐Driven Change: The Role of Skill Composition, Task Structure, and Psychosocial BuffersAmerican Journal of Industrial Medicine · 2026
16. A Truncated Serpin D1 Variant Regulates Adseverin-Dependent Actin Severing and Is Required for OsteoclastogenesisCells · 2026
17. Difficult-to-treat systemic lupus erythematosus: from refractory disease to a multidimensional clinical trajectoryJournal of Autoimmunity · 2026
18. Subthalamic stimulation modulates working memory-related cortical dynamics in Parkinson’s diseaseBrain Communications · 2026
19. Galectin-1 Modulates Cell Adhesions, Cavin-1 phosphorylation, and Vascular Permeability in Kidney Endothelial Cells – Insights from Proteomics, Phosphoproteomics, and Functional StudiesMolecular & Cellular Proteomics · 2026
20. Future Prospects of Ultrasound: Role of Low‐Intensity Transcranial Ultrasound Stimulation in the Treatment of Neurological and Psychiatric DisordersEuropean Journal of Neurology · 2026