Ludwig Cancer Research

Recent papers from Ludwig Cancer Research

1. The TCR Motif Atlas: a database of specificities for TCRs recognizing viral, cancer, and autoimmune epitopesNucleic Acids Research · 2026
2. Spatiotemporal remodeling in habenula marks the onset of depression-related phenotypesNature Neuroscience · 2026
3. AlloPool is a deep learning framework that infers protein allostery from molecular dynamics simulationsPLoS Biology · 2026
4. Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen speciesScience · 2026
5. Dendritic cells as programmable platforms for cancer immunotherapyTrends in Immunology · 2026
6. Mechanisms of neuropeptide-mediated immune sensing in the modulation of antitumor immunityJournal for ImmunoTherapy of Cancer · 2026
7. Programmed cell death-1: from a T-cell immune checkpoint to a regulator of Natural Killer cell biologyFrontiers in Cell and Developmental Biology · 2026
8. Lymphatic vessels invade bone in disease but are absent in health and regenerationCell · 2026
9. The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogrammingNature Aging · 2026
10. Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5 ⁺ tumor stem cell lineage commitment upon Wnt depletionScience Advances · 2026
11. Structure-conditioned self-supervised learning of residue interaction constraints in protein kinases for variant interpretationBioinformatics · 2026
12. Mechanoreceptor plexin D1 regulates lymphatic valve morphogenesis and lymphedema pathogenesisJournal of Clinical Investigation · 2026
13. Driving tumor-associated macrophages to a CXCL9Hi/SPP1Low phenotype eliminates pancreatic cancerCell Reports Medicine · 2026
14. Reversal of T cell exhaustion enables cancer vaccine efficacy in BRCA1-deficient ovarian canceriScience · 2026
15. Spatially Defined Cellular Niches Forged by Tumor-Intrinsic MHCII Redefine Immune Competence in Ovarian CancerCancer Discovery · 2026
16. Cathepsin S regulates germinal center reactions and anti-tumor humoral responsesThe Journal of Experimental Medicine · 2026
17. Aquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironmentsThe Journal of Experimental Medicine · 2026
18. Pre-operative intratumoral toll-like receptor 9 (TLR9) agonist vidutolimod (Vidu) and stereotactic body radiation therapy (SBRT) in early triple-negative breast cancer (eTNBC): Randomized phase 2 CyberImmunoBreast trial.Journal of Clinical Oncology · 2026
19. Multi-omics analysis from the IMMUcan consortium to identify predictors of chemo-immunotherapy response in early-stage triple-negative breast cancer.Journal of Clinical Oncology · 2026
20. NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulationThe EMBO Journal · 2026