Latvijas Organiskās Sintēzes Institūts

Recent papers from Latvijas Organiskās Sintēzes Institūts

1. HMGCR Inhibition Impairs Mitochondrial Fatty Acid Oxidation in Clinical and Preclinical Models: Therapeutic Targeting of Long-Chain Acylcarnitines2026
2. Systematic assessment of transcriptomic and phenotypic biological profiling for mechanism-based hazard assessment using target-annotated reference chemicals in renal proximal tubular epithelial cellsArchives of Toxicology · 2026
3. Ultrafast MAS and Deuteration for High‐Resolution Proton Detected Solid‐State NMR of Intact Fungal Cell WallsChemBioChem · 2026
4. DNAharvester: A Nextflow Pipeline for Analysing Highly Degraded DNA from Ancient and Historical SpecimensBioinformatics · 2026
5. Lysine-Based Amphiphiles with Pyrrole, Furan and Thiophene LinkersMolbank · 2026
6. LEAP2 mediates long-term inhibition of orexigenic neurons of the hypothalamus in miceProceedings of the National Academy of Sciences · 2026
7. Unanticipated intermediates during isopenicillin N synthase catalysis identified by time-resolved X-ray free-electron laser studiesNature Catalysis · 2026
8. The intake of omega-3 fatty acids and the inhibition of their mitochondrial metabolism increase EPA and DHA levels in healthy volunteersLipids in Health and Disease · 2026
9. Recovery of genomic and transcriptomic profiles from decades-old FFPE brain tissuesScientific Reports · 2026
10. Targeting the AcrAB-TolC efflux pump by small molecules selectively addressing the outer membrane factor TolCFrontiers in Pharmacology · 2026
11. 3,5‐Dicyanopyridine–Phenothiazine Derivatives Exhibiting Single‐Molecular White Emission for Down‐Converting Electroluminescent DevicesAdvanced Optical Materials · 2026
12. Evaluation of Potential Second-Generation Manufacturing Routes to PalbociclibOrganic Process Research & Development · 2026
13. Deconstruction of Aspartic Protease Inhibitors Enables Fragment‐Based Discovery of Plasmepsin V InhibitorsChemMedChem · 2026
14. Adenosine5′-Carboxamide-Based Inhibitors ofMETTL1ACS Medicinal Chemistry Letters · 2026
15. Facile Synthesis of Indole–, Pyrazole–, and Indazole–Pyrrolidine Hybrids as Novel Chiral Heterocyclic Building BlocksMolecules · 2026
16. Identificationof a Novel 1,3,4-Thiadiazole-BasedScaffold as a Plasmepsin V InhibitorACS Omega · 2026
17. High Radiative Rate and Brightness Electroluminescent Cu(I) Complexes via Carbene‐Induced Electronic Coupling EnhancementAdvanced Optical Materials · 2026
18. Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysisEuropean Journal of Pharmacology · 2026
19. Sultams as Dual Inhibitors of Human Carbonic Anhydrase and Thioredoxin ReductaseChemMedChem · 2026
20. Antibacterial and antibiofilm effects of natural phenolic acids: Insights into structure-function relationships, extracellular pH, and morphological changesMicrobiology Spectrum · 2026