MRC London Institute of Medical Sciences

Recent papers from MRC London Institute of Medical Sciences

1. Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortiumMolecular Psychiatry · 2025
2. Comparison of Clinical Characteristics Between Patients With HCM With Nontruncating Versus Truncating Variants in MYBPC3Circulation Genomic and Precision Medicine · 2026
3. Self-organization of Drosophila chromatin architecture in a cell-free systemEMBO Reports · 2026
4. Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibitionNeuro-Oncology · 2026
5. WEE1 opposes APC/CCDH1 activity to promote S phase entryNature · 2026
6. The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trialNature Communications · 2026
7. The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trialNature Communications · 2026
8. Developmental contexts of gene-regulatory evolution following whole genome duplication in salmonidsNature Ecology & Evolution · 2026
9. Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and FliesAging Cell · 2026
10. The mechanism underlying tardive dyskinesia: an exploratory test of the dopamine overactivity hypothesis using MRI imaging of midbrain neuromelaninPsychopharmacology · 2026
11. Redox activation of ATG5 licenses autophagy upon nutrient restriction2026
12. Plasma membrane order maps functional diversity in immune cellsNature Chemical Biology · 2026
13. Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonismNature Communications · 2026
14. Beyond BMI: Mapping the landscape of adiposity and cardiovascular riskEuropean Heart Journal · 2026
15. Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiationNature Communications · 2026
16. The sex and reproductive plasticity of intestinal muscles instruct gut sizeCell · 2026
17. A conserved residue in the histidine kinase BceS tunes bacitracin stress responses in Bacillus subtilisAccess Microbiology · 2026
18. Cannabis‐Based Medicinal Products for Endometriosis: A 2‐Year Prospective Analysis From the UK Medical Cannabis RegistryAustralian and New Zealand Journal of Obstetrics and Gynaecology · 2026
19. Mitochondrial metabolism and epigenetic crosstalk drive SASPNature · 2026
20. Mechanisms of MCM2–7 helicase activation and initial DNA melting at near base-pair resolutionNature Communications · 2026