MRC Mitochondrial Biology Unit

Recent papers from MRC Mitochondrial Biology Unit

1. Cryo-EM structures of Cereibacter sphaeroides ferrochelatase reveal an oligomeric state that occludes the substrate-binding site2026
2. Visual acuity changes in idebenone treatment‑naïve patients with Leber hereditary optic neuropathy: insights from the CRS-2 studyJournal of Neurology · 2026
3. Management of Acute-Onset Exogenous Endophthalmitis in French University Hospitals: A Multicenter Retrospective StudyOphthalmology and Therapy · 2026
4. Survival and causes of death in primary mitochondrial diseasesGenome Medicine · 2026
5. Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicityNature Chemical Biology · 2026
6. Golgi-derived vesicles containing PI(3,4)P 2 drive mitochondrial fusionScience · 2026
7. Mapping human visual contrast sensitivity and vision loss across the visual field with model-based fMRIeLife · 2026
8. Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cyclingScience · 2026
9. Mitochondrial membrane lipid cardiolipin controls fiber-type adaptations in aging muscle via estrogen-related receptor γNature Aging · 2026
10. Smartphone-Based 3D Ocular Reconstruction for Automated Quantitative Blepharoptosis EvaluationJAMA Ophthalmology · 2026
11. The Batten disease protein CLN8 is a stereospecific acyltransferase in bis(monoacylglycero)phosphate biosynthesisNature Cell Biology · 2026
12. Batten disease protein CLN8 enables a non-canonical phospholipid synthesis pathwayNature Cell Biology · 2026
13. Allotopic Expression of ND6 Restores Vision in a Mitochondrial Disease ModelJCI Insight · 2026
14. Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen speciesScience · 2026
15. Maternal DNA repair safeguards genome stability during the oocyte-to-embryo transitionMolecular Human Reproduction · 2026
16. Should taurine be pursued further as a supportive nutraceutical for Duchenne muscular dystrophy? Gathering evidence in a zebrafish disease model to confirm or refute the benefits - Stage 1 ReportFrontiers in Nutrition · 2026
17. NAD⁺ or β-Hydroxybutyrate Each Protects Against Tachypacing-induced Metabolic Remodeling Through Regulation of Mitophagy in HL-1 CardiomyocytesAJP Cell Physiology · 2026
18. Protein thiol alterations drive pathologic liquid–liquid phase separation in the aging brainNature Structural & Molecular Biology · 2026
19. The Toll‐Like Receptor Signalling Pathway Is Altered in iPSC ‐Derived Cortical Networks From People With Bipolar DisorderBipolar Disorders · 2026
20. The pseudouridine synthase PUSL1 modifies U39 of mitochondrial tRNAs and is linked to human neurological phenotypesNucleic Acids Research · 2026