MRC Cancer Unit

Recent papers from MRC Cancer Unit

1. HRDPath: an explainable multi-model deep learning architecture for predicting homologous recombination deficiency from histopathology imagesNature Communications · 2026
2. Cabergoline Suppresses Postpartum Breast Cancer by Enhancing Mammary Gland Involution in Brca1-Mutant Mice and Is Associated with Reduced Risk in Younger WomenCancer Discovery · 2026
3. Cancer-associated fibroblast subtypes differentially modulate natural killer cells in cancerCell Reports · 2026
4. Is cancer increasing in young adults in Spain? Incidence trends from the Spanish Network of Cancer Registries (REDECAN)European Journal of Cancer · 2026
5. Sleep Regularity and Age-Related Eye Diseases: Prospective Analyses with Retinal Imaging and Multimorbidity Assessment in the UK BiobankSLEEP · 2026
6. Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal CancerAdvanced Science · 2026
7. Estimating thresholds for risk of cannabis use disorder using standard delta‐9‐tetrahydrocannabinol (THC) unitsAddiction · 2026
8. Structure of the Gq-coupled adhesion receptor ADGRL4Nature Communications · 2025
9. Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilitiesEMBO Molecular Medicine · 2025
10. FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancerEMBO Reports · 2025
11. HRDPath: An Explainable Multi-Model Deep Learning Architecture for Predicting Homologous Recombination Deficiency from Histopathology Images2025
12. Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation2025
13. Single-cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predispositionCell Genomics · 2025
14. Deuterium Metabolic Imaging of the Human Abdomen at Clinical Field StrengthInvestigative Radiology · 2025
15. RPGR regulates motile cilia by interfering with actin dynamics2025
16. Polycomb-associated and Trithorax-associated developmental conditions—phenotypic convergence and heterogeneityEuropean Journal of Human Genetics · 2025
17. Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinomaScientific Reports · 2024
18. TAp73 regulates mitochondrial dynamics and multiciliated cell homeostasis through an OPA1 axisCell Death and Disease · 2024
19. KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO12024
20. Identification of candidate causal variants and target genes at 41 breast cancer risk loci through differential allelic expression analysisScientific Reports · 2024