Genomics Institute of the Novartis Research Foundation

Recent papers from Genomics Institute of the Novartis Research Foundation

1. Dynamic remodeling of the KRAS interactome by direct RAS inhibitors with distinct mechanism of action reveals convergent responsesOncogene · 2026
2. IL-2 mutein-engrafted antibody MHS552 selectively expands functional regulatory T cells in nonclinical models and healthy participantsNature Communications · 2026
3. Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical ValidationJournal of Medicinal Chemistry · 2026
4. Abstract LB360: Targeted degradation of p300 and CBP via antibody-drug conjugate in prostate cancer cellsCancer Research · 2026
5. A diffusion model conditioned on compound bioactivity profiles for generating high-content imagesScientific Reports · 2026
6. Hypertension management in São Paulo: insights from a computational simulation approachThe Lancet Regional Health - Americas · 2026
7. A chikungunya virus-like particle vaccine reduces chikungunya disease in cynomolgus macaques and protection is mediated by antibody transferred from vaccinated humansnpj Vaccines · 2026
8. Comparison of neonatal systemic and intracerebroventricular AAV9 gene therapy delivery demonstrating improved behavioral and phenotypic outcomes in a mouse model of Niemann-Pick disease, type C1PLoS ONE · 2026
9. Delpacibart etedesiran improves the molecular pathology of myotonic dystrophy type 1 in the phase 1/2 MARINA studyMolecular Therapy · 2026
10. High-throughput assay for measuring target occupancy of covalent compounds: a case study with MK2RSC Chemical Biology · 2026
11. Mapping the Dynamic Complexity of Hypertension Management in São Paulo, BrazilInternational Journal of Public Health · 2026
12. Metadata assessment of non-human primate studies of AAV9 uncovers potential tissue specific variation in expression efficiencyGene Therapy · 2026
13. Intermittent AP-1 activation in muscles contributes to exercise-induced health benefits2026
14. Identification and characterization of a novel inhibitor of influenza A virus that acts by blocking nucleoprotein oligomerizationAntimicrobial Agents and Chemotherapy · 2025
15. Circulating causal protein networks linked to future risk of myocardial infarctionNature Communications · 2025
16. Systematic comparison of observational and Mendelian Randomization estimates for cardiometabolic proteomic signatures2025
17. Transcriptional changes in non-human primate tissues after intrathecal delivery of serotype 9 adeno-associated viral vector: Insights into organ toxicitiesMolecular Therapy — Methods & Clinical Development · 2025
18. Impact of pre-existing immunity on safety and biodistribution of a single AAV9 vector intrathecal injection in cynomolgus monkeysMolecular Therapy — Methods & Clinical Development · 2025
19. Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout miceScience Advances · 2025
20. Cryo-EM structures of Nipah virus polymerases and high-throughput RdRp assay development enable anti-NiV drug discoveryNature Communications · 2025