Charles River Laboratories (United States)

Recent papers from Charles River Laboratories (United States)

1. Preclinical Development and Safety of Laterally Spreading Dual AAV.SPR-MYO7A Vectors for the Treatment of Usher Syndrome Type 1B2026
2. Synchrotron-Generated X-Ray Microbeam Irradiation Enhances Hippocampal Neurogenesis in Healthy RatsRadiation Research · 2026
3. AAV Gene Augmentation Therapy Rescues the Phenotype in the RDH5 −/− Cat Model of Fundus AlbipunctatusInvestigative Ophthalmology & Visual Science · 2026
4. Asticcacaulis aquihabitans sp. nov., a novel psychrotrophic member of the phylum Pseudomonadota isolated from Lake Michigan potable waterINTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · 2026
5. Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case seriesThe Lancet · 2025
6. Least significant differences for QT and QTc intervals in regulatory toxicology studies using jacketed external telemetry in canines and non-human primatesJournal of Pharmacological and Toxicological Methods · 2026
7. Examining moxifloxacin QTc sensitivity in the canine to support ICH E14/S7B Q&A compliant studies using a parallel ascending and an ascending dosing schemeJournal of Pharmacological and Toxicological Methods · 2026
8. A retrospective review of multi-lead jacketed telemetry collections in 2023 for quality endpointsJournal of Pharmacological and Toxicological Methods · 2026
9. A comparative review of cardiovascular historical control data sets in dogs across three different test facilities applying similar best practice data collection and analysis proceduresJournal of Pharmacological and Toxicological Methods · 2026
10. Comparative evaluation of artificial intelligence-based and pathologist scoring of murine bile duct hyperplasiaVeterinary Pathology · 2026
11. Case Studies in Identifying and Understanding Seizure Liability in Drug DevelopmentInternational Journal of Toxicology · 2026
12. Scientific perspectives on in vivo developmental neurotoxicity testing: study design, regulatory context, and future directionsArchives of Toxicology · 2026
13. Preclinical Safety Evaluation of Human Lactoferrin Alpha (Effera ® )International Journal of Toxicology · 2026
14. Performance of a deep learning–based convolutional neural network for quantification of outer retina atrophy compared with in vivo imaging and manual histologic scoringVeterinary Pathology · 2026
15. Key challenges for in vitro testing of oral tobacco and nicotine products for regulatory applications: Recommendations for using in vitro toxicity and disease modelsAlternatives to Laboratory Animals · 2026
16. Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington’s disease pathogenesis in miceScience Translational Medicine · 2026
17. Enumeration of Microscopic Ovarian Structures in Rodents: Best Practices and Toxicological SignificanceBirth Defects Research · 2026
18. Automating CAR T cell Manufacturing Across Distinct Platforms Delivers Similar Cell Quality, Phenotype, and Function.Cytotherapy · 2026
19. Assay-dependent Artifactual Prolongation of Activated Partial Thromboplastin Time (aPTT) in Cynomolgus Monkeys: Potential Role of POEGMAInternational Journal of Toxicology · 2026
20. Antisense oligonucleotide treatment following viral delivery of artificial SOD1-targeting miRNA shows improved efficacy in SOD1-G93A miceMolecular Therapy Advances · 2026