Centre d'Etudes et de Recherche sur le Médicament de Normandie

Recent papers from Centre d'Etudes et de Recherche sur le Médicament de Normandie

1. Design, synthesis and biological evaluation of pleiotropic prodrugs activated by cholinesterases and releasing a 5-HT4R agonist, with in vivo antiamnesic activity.European Journal of Medicinal Chemistry · 2026
2. Carltonine B derivatives: Synthesis and structure-activity relationship insights for selective butyrylcholinesterase inhibitionBioorganic Chemistry · 2026
3. Radiobiology Contributions and Perspectives in Hadron Therapy, With a Focus on Carbon Ions: Report From the Workshop Hadron Therapy for Life, Caen, March 2025International Journal of Particle Therapy · 2025
4. Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole DerivativePharmaceutics · 2025
5. A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability DeficitsBrain Sciences · 2024
6. Disruption of PHF6 Peptide Aggregation from Tau Protein: Mechanisms of Palmatine Chloride in Preventing Early PHF6 AggregationACS Chemical Neuroscience · 2024
7. Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disordersMedicinal Research Reviews · 2024
8. Navigating pharmacophore space to identify activity discontinuities: A case study with BCR‐ABLMolecular Informatics · 2024
9. MRI-based microthrombi detection in stroke with polydopamine iron oxideNature Communications · 2024
10. Studies on the mechanisms of action of MR33317Naunyn-Schmiedeberg s Archives of Pharmacology · 2024
11. Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapyNature Communications · 2024
12. Synthesis and interest in medicinal chemistry of β-phenylalanine derivatives (β-PAD): an update (2010–2022)Future Medicinal Chemistry · 2024
13. A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activityCell Death and Disease · 2024
14. Molecular glue degraders: exciting opportunities for novel drug discoveryExpert Opinion on Drug Discovery · 2024
15. Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective AgentsMolecules · 2024
16. Unsymmetrical Low-Generation Cationic Phosphorus Dendrimers as a Nonviral Vector to Deliver MicroRNA for Breast Cancer TherapyBiomacromolecules · 2024
17. Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinasesRSC Medicinal Chemistry · 2024
18. Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applicationsJournal of Materials Chemistry B · 2024
19. A Biomimetic Multiparametric Assay to Characterise Anti-Amyloid DrugsInternational Journal of Molecular Sciences · 2023
20. Towards a partial order graph for interactive pharmacophore exploration: extraction of pharmacophores activity deltaJournal of Cheminformatics · 2023