Sangamo BioSciences (United States)

Recent papers from Sangamo BioSciences (United States)

1. Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug TestingJournal of the American College of Cardiology · 2014
2. Engineered zinc finger repressors induce a prolonged and selective repression of SCN9A in nociceptors of nonhuman primatesScience Translational Medicine · 2026
3. Perspectives on PCR-Based Cellular Kinetics and Biodistribution Analysis for Emerging Adoptive Cell TherapiesThe AAPS Journal · 2026
4. 2025 White Paper on Recent Issues in Bioanalysis: Biomarkers Calibrators & Stability; Evaluation of NULISA; Neurofilament & Autoantibody Biomarker Assays; Removing IgM Interference; ELISpot & FluoroSpot Best Practices; Modular HD Cytometry; Single-cell Analysis Imaging Cytometry (PART 2A – Recommendations on Biomarkers Discovery, Development, Validation & Regulatory Approval, Ligand-Binding Assays (LBA) and Cell-Based Assays (CBA) PART 2B – Regulatory Agencies’ Input on Biomarkers, IVD/CDx and Biomarker Assay Validation (BAV))Bioanalysis · 2026
5. 2025 White Paper on Recent Issues in Bioanalysis: Redosing Patients with AAV Gene Therapy; CRS Immunogenicity Risk; Shedding Assays; NHP Studies Immunogenicity; CMC vs Bioanalytical Assays; Artificial Intelligence-Powered Genomic Pipelines for NGS ( PART 3A – Recommendations on Gene, Cell, and Vaccine Therapies Immunogenicity & Technologies; Biotherapeutics & Biosimilars Immunogenicity Assessment & Clinical Relevance PART 3B – Regulatory Agencies’ Input on Immunogenicity/Technologies of Biotherapeutics, Gene, Cell & Vaccine Therapies)Bioanalysis · 2025
6. Enhanced anti-tumor activity by zinc finger repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILsMolecular Therapy Oncology · 2025
7. Zinc Finger Repressors mediate widespread PRNP lowering in the nonhuman primate brain and profoundly extend survival in prion disease mice2025
8. Mutagenesis and Carcinogenesis Risk Evaluation for AAV and Lentiviral Gene TherapiesInternational Journal of Toxicology · 2025
9. A serum- and feeder-free system to generate CD4 and regulatory T cells from human iPSCsStem Cells · 2025
10. 2024 White Paper on Recent Issues in Bioanalysis: Evolution of Immunogenicity Assessment beyond ADA/NAb; Regulated Genomic/NGS Assays; Hypersensitivity Reactions; Minimum Noise Reduction; False Positive Range; Modernized Vaccine Approaches; NAb/TAb Correlation (PART 3A – Recommendations on Advanced Strategies for Molecular Assays and Immunogenicity of Gene Therapy, Cell Therapy, Vaccine; Biotherapeutics Immunogenicity Assessment & Clinical Relevance PART 3B – Regulatory Agencies’ Input on Immunogenicity/Technologies of Biotherapeutics, Gene, Cell & Vaccine Therapies)Bioanalysis · 2025
11. 2024 White paper on recent issues in bioanalysis: Impact of LDT in US and IVDR in EU; AI/ML for High Parameter Flow Cytometry; The rise of Olink Technology; CDx for AAV Gene Therapies; Integrative Bioanalysis by Multiple Platforms; Super Sensitive ADA/NAb LBA ( PART 2A – Recommendations on Advanced Strategies for Biomarkers, IVD/CDx Assays (BAV), Cell Based Assays (CBA), and Ligand-Binding Assays (LBA) PART 2B – Regulatory Agencies’ Input on Biomarkers, IVD/CDx, and Biomarker Assay Validation)Bioanalysis · 2025
12. Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptiveAndrology · 2024
13. Paracrine regulations of IFN-γ secreting CD4 + T cells by lumican and biglycan are protective in allergic contact dermatitis2024
14. MOG-specific CAR Tregs: a novel approach to treat multiple sclerosisJournal of Neuroinflammation · 2024
15. Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell diseaseScientific Reports · 2024
16. Enhanced anti-tumor activity by Zinc Finger Repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs2024
17. IL23R-specific CAR Tregs for the treatment of Crohn’s diseaseJournal of Crohn s and Colitis · 2024
18. Assessment of Adeno-Associated Virus Purity by Capillary Electrophoresis-Based WesternMolecular Therapy — Methods & Clinical Development · 2024
19. Neutralizing Antibody Sample Testing and Report HarmonizationThe AAPS Journal · 2024
20. MOG-specific CAR Tregs: a novel approach to treat multiple sclerosis2024