Eli and Edythe Broad Foundation

Recent papers from Eli and Edythe Broad Foundation

1. Germline EGFR T790M mutation and lung cancer riskScience · 2026
2. Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein responseNature Communications · 2026
3. Vegetation, Water Infiltration, and Soil Carbon Responses to Adaptive Multi‐Paddock and Conventional Grazing in Northern Great Plains, USA, RanchesJournal of Sustainable Agriculture and Environment · 2026
4. Cell-free chromatin epigenomic profiling enables non-invasive pancreatic cancer cell-state identification2026
5. Patterns of lung cancer incidence in adults diagnosed under age 50 in the United States, 2000–2021Cancer · 2025
6. Lymphotoxin-driven cancer cell eradication by tumoricidal CD8 ⁺ TIL2025
7. BESTDR Enables Bayesian Quantification of Mechanism-Specific Drug ResponsesCancer Research · 2025
8. Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers2025
9. Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancerseLife · 2025
10. GPCR Antagonism via Antibody-Mediated Rewiring of Receptor Trafficking and Degradation2025
11. Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancernpj Precision Oncology · 2025
12. Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers2025
13. KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavageNature Genetics · 2025
14. Human Plasma Proteomics Links Modifiable Lifestyle Exposome to Disease Risk2025
15. Early dynamics of clinical and laboratory parameters predict primary refractory disease in patients with metastatic urothelial carcinoma receiving atezolizumabJournal for ImmunoTherapy of Cancer · 2025
16. Active and Passive Vector Surveillance Systems in Lyme Endemic Minnesota and Their Correlation to Human DiseaseJournal of Public Health Management and Practice · 2025
17. The Germline and Somatic Origins of Prostate Cancer HeterogeneityCancer Discovery · 2025
18. ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancerCell Reports · 2024
19. Decoding the epigenetics and chromatin loop dynamics of androgen receptor-mediated transcriptionNature Communications · 2024
20. Notch induces transcription by stimulating release of paused RNA polymerase IIGenes & Development · 2024