The Microsoft Research - University of Trento Centre for Computational and Systems Biology

Recent papers from The Microsoft Research - University of Trento Centre for Computational and Systems Biology

1. Critical role for the TGF-β1/mTORC1 signaling axis in defining the transcriptional identity of CTHRC1 + pathologic fibroblastsScience Advances · 2026
2. Quantitative Systems Pharmacology (QSP): Bridging Biology and Mechanism with Clinical Drug Development DecisionsThe Journal of Clinical Pharmacology · 2026
3. Multivariate Survival Analysis of a Comprehensive Clinical Trial of Rapamycin in Amyotrophic Lateral Sclerosis Explores Prognostic Factors and Survival Patterns in C9orf72 CarriersEuropean Journal of Neurology · 2026
4. Physiologically based pharmacokinetic modeling of mRNA therapeutics: A multiscale framework for LNP and antibody trafficking in miceMolecular Therapy — Nucleic Acids · 2026
5. A mathematical model of folate-mediated one-carbon metabolism in Down syndromenpj Systems Biology and Applications · 2026
6. From Airways to Arteries: Dissecting the Inflammatory Mechanisms of Pulmonary Vascular Remodeling in a Murine Model of Chronic Airway InflammationBiomedicines · 2026
7. Predicting Aberrant Fc-fusion Protein Pharmacokinetics from In Silico Structural Properties and Physiologically Based Pharmacokinetic (PBPK) ModelingThe AAPS Journal · 2026
8. Association between plasma glucosylsphingosine levels and dyskinesia burden in GBA1-related Parkinson's diseaseNeurobiology of Disease · 2026
9. HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequencesNucleic Acids Research · 2025
10. A novel approach to quantify out-of-distribution uncertainty in Neural and Universal Differential Equations2025
11. Transforming Pediatric Rare Disease Drug Development: Enhancing Clinical Trials and Regulatory Evidence With Virtual PatientsCPT Pharmacometrics & Systems Pharmacology · 2025
12. CSpace: a concept embedding space for biomedical applicationsBioinformatics · 2025
13. A multiscale physiologically based pharmacokinetic model to support mRNA-encoded BiTE therapy in cancer treatmentMolecular Therapy — Nucleic Acids · 2025
14. A mechanistic model of pure and lipidic α-synuclein aggregation for advancing Parkinson’s therapiesCommunications Chemistry · 2025
15. A Multiscale Quantitative Systems Pharmacology Model for the Development and Optimization of mRNA VaccinesCPT Pharmacometrics & Systems Pharmacology · 2025
16. Longitudinal transcriptomic analysis of the hyperoxia-exposed preterm rabbit as a model of BPDFrontiers in Pediatrics · 2025
17. Quorum Sensing Model Structures Inspire the Design of Quorum Quenching StrategiesIEEE Transactions on Molecular Biological and Multi-Scale Communications · 2025
18. The interplay between oxidative stress and inflammation supports autistic-related behaviors in Cntnap2 knockout miceBrain Behavior and Immunity · 2025
19. stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatmentsFrontiers in Pharmacology · 2025
20. Robust parameter estimation and identifiability analysis with hybrid neural ordinary differential equations in computational biologynpj Systems Biology and Applications · 2024