Light Chain Bioscience (Switzerland)

Recent papers from Light Chain Bioscience (Switzerland)

1. A reciprocally masked anti-CD47/IL-2 fusion protein promotes antitumor immunity and limits systemic toxicityCancer Immunology Research · 2026
2. Combination of bispecific antibodies enable targeted TNFRSF agonism and effective antitumor activityMolecular Therapy · 2026
3. A third-generation, high-affinity biparatopic anti-tau antibody inhibits intracellular tau aggregation seeded by Alzheimer’s brain extractsAlzheimer s Research & Therapy · 2026
4. Beyond a Single ADV Threshold: Toward Reproducible Production and Comprehensive Acoustic Characterization of Perfluorocarbon NanodropletsUltrasound in Medicine & Biology · 2026
5. Cliramitug for depletion of cardiac amyloid transthyretin: long-term follow-up of the NI006-101 trialNature Medicine · 2026
6. An Investigation of the APOE4 Association with Tau Pathology and Cognitive DeclineThe EANM Journal · 2026
7. Abstract 5532: Bispecific antibodies targeting EGFR and HER2 for effective killing of solid tumor cells via a safe CD47-SIRPA modulationCancer Research · 2026
8. Abstract 5553: Tumor-selective activation of 4-1BB receptor via bispecific antibody combinationsCancer Research · 2026
9. Independent and interactive contributions of white matter hyperintensities and Alzheimer’s disease imaging and plasma biomarkers to cognitive decline in older adults without dementiaAlzheimer s Research & Therapy · 2026
10. Predicting cognitive decline with amyloid‐PET, plasma p‐tau217, Aβ42/40, and p‐tau217/Aβ42 in a community‐based cohort – relevance for clinical trial enrollmentAlzheimer s & Dementia · 2025
11. Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer’s disease: associations with Aβ, tau, synaptic proteins and APOE ε4Translational Neurodegeneration · 2025
12. Tumor-dependent myeloid and lymphoid cell recruitment in genO-BRGSF-HIS mice: a novel tool for evaluating immunotherapiesFrontiers in Immunology · 2025
13. Crizanlizumab and inclacumab are equally potent inhibitors of cell adhesion in the blood of patients with sickle cell diseaseBlood Red Cells & Iron · 2025
14. Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalkNature Communications · 2025
15. White Matter Hyperintensities Impact Biomarker Prediction of Cognitive Decline2025
16. Protective Effects of Socioeconomic Status and Lifestyle on Amyloid- and White Matter Hyperintensity-Related Longitudinal Brain Atrophy and Cognitive Decline.2025
17. Strain-Distinct α-Synuclein and Tau Cross-Seeding Uncovered by Correlative Approach with Optical Photothermal Infrared Sub-Micron ImagingJournal of the American Chemical Society · 2025
18. Hippocampal iron patterns in aging and mild cognitive impairmentFrontiers in Aging Neuroscience · 2025
19. Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineGeroScience · 2025
20. Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodiesJournal for ImmunoTherapy of Cancer · 2025