National Centre for the Replacement Refinement and Reduction of Animals in Research

Recent papers from National Centre for the Replacement Refinement and Reduction of Animals in Research

1. Supporting 3Rs approaches in biologicals testing: responses from a survey of Manufacturers, Contract Research Organisations, National Control Laboratories and National Regulatory AuthoritiesBiologicals · 2026
2. Regulatory momentum for new approach methodologies (NAMs) in medicines development: from vision to implementationCurrent Opinion in Toxicology · 2026
3. Reporting and transparency in laboratory animal science: Past achievements, present concerns and future directionsLaboratory Animals · 2026
4. Launching SIRF-UP: a practical pathway for sex-inclusive animal research governanceLaboratory Animals · 2026
5. Animal research in the UK: Regulation, implementation, welfare and development of new approach methodologiesAnimal Models and Experimental Medicine · 2026
6. 25 years of applying the 3Rs principles in safety pharmacology: success stories and future perspectivesFrontiers in Physiology · 2026
7. Best Practices for the Development and Application of Bioinformatics Approaches for Species Extrapolation in Chemical Safety AssessmentIntegrated Environmental Assessment and Management · 2026
8. Considerations related to dose selection for regulatory animal testingCurrent Opinion in Toxicology · 2026
9. Evaluating Behavioral Management Practices for Laboratory Nonhuman Primates: An International SurveyAnimals · 2026
10. Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compoundsFrontiers in Toxicology · 2025
11. Minimizing use of nonhuman primates to inform risk to fertility and of adverse pregnancy outcomes with pharmaceuticalsRegulatory Toxicology and Pharmacology · 2025
12. Workshop Report: Scoping for the Development of a Proposal for an OECD Guidance Document on Fish Vitellogenin AssessmentIntegrated Environmental Assessment and Management · 2025
13. The Sex Inclusive Research Framework to address sex bias in preclinical research proposalsNature Communications · 2025
14. Best practices for blood collection and anaesthesia in mice: Selection, application and reportingBritish Journal of Pharmacology · 2025
15. Ability to predict irregular periods of food deprivation improves body-weight regulation and reduces weight gain in food-insecure starlings2025
16. Microsampling in toxicology studies – maximising the scientific, business and 3Rs advantagesToxicology Research · 2025
17. Use of alternatives to animal testing for Environmental Safety Assessment (ESA): Report from the 2023 EPAA partners’ forumRegulatory Toxicology and Pharmacology · 2025
18. Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug developmentALTEX · 2025
19. Promoting reusable and open methods and protocols (PRO-MaP) can improve methodological reporting in the life sciencesPLoS Biology · 2024
20. Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus ArticleHuman Gene Therapy · 2024