Krembil Brain Institute

Recent papers from Krembil Brain Institute

1. Efficacy, safety, and tolerability of lysergic acid diethylamide for the treatment of depressive symptoms: A meta-analysis and systematic reviewJournal of Psychopharmacology · 2026
2. Canadian Spine SocietyLongitudinal changes in comprehensive radiographic parameters following short-segment surgery (1–2 levels) for degenerative lumbar spondylolisthesisMeasuring spinopelvic parameters in patients with 6 lumbar vertebrae: a matched comparison of asymptomatic volunteersSupervised and unsupervised machine learning reveals distinct clinical phenotypes across degenerative lumbar conditions: sex-specific clustering for personalized surgical careDoes disc degeneration matter? Outcomes of decompression-alone surgery in low-grade spondylolisthesisIntervertebral disc degeneration in humans: altered peripheral immune cell profile in patients and inflammation-mediated matrix metalloproteinase upregulation in human disc cellsDomino toppling: when the disruption of one disc negatively impacts its neighbour. An investigation into the mechanism of adjacent segment diseaseMultimodal analgesia after surgery for thoracolumbar spinal stenosisLumbar foraminal morphology can affect outcomes of indirect decompression: a novel classificationPredictors of intraoperative vascular complications during anterior lumbar spinal exposure: a retrospective analysisHigher rates of fusion with porous titanium than with polyetheretherketone (PEEK) lumbar interbody cages: a retrospective cohort studyCan measuring preoperative postvoid urine residual values influence care in patients undergoing elective spine surgery?To respond or not to respond: the many faces of recovery after lumbar spine surgeryPostoperative outcomes in primary versus revision lumbar decompressive surgery: a propensity-matched analysisWhat are the barriers and enablers influencing physical activity among patients awaiting spine surgery? A qualitative study guided by the Theoretical Domains FrameworkEffects of childbearing on spinopelvic alignmentClinical and radiological outcomes of biportal endoscopic lumbar interbody fusion using oblique lateral interbody fusion-type cage: preliminary results and learning curve analysisArtificial intelligence for spine surgery education: a comparative analysis of ChatGPT and DeepSeek performanceSpineNavigator: a surgeon-trained large language model to enhance communication and patient education in spine surgeryDoes comorbidity count, ASA score, or Quan-modified Charlson Comorbidity Index score better predict morbidity after elective spinal surgery?Factors associated with perioperative adverse events in patients with degenerative lumbar spondylolisthesisImplementation of an awake spine surgery program in Canada: lessons learned from the surgeon’s perspectiveLongitudinal finite mixture models for mining complex prognostic phenotypes of degenerative cervical myelopathyEnvironmental impacts of a cervical laminectomy and fusion procedure from first consultation to patient recovery: insights from a life cycle assessmentReframing mild degenerative cervical myelopathy: insights from a latent profile analysisPredictive algorithm for treatment recommendation between operative and nonoperative management in mild degenerative cervical myelopathyMachine learning classification of patients with degenerative cervical myelopathy into clinically relevant clusters and development of an adoptable clinical algorithmReassessing the minimal clinically important differences of patient-reported outcomes in cervical myelopathy: a patient-centred approach from the Canadian Spine Outcomes and Research NetworkCurrent practices in return-to-play recommendations for recreational athletes following cervical spine surgeries: a preliminary global surveyCage subsidence and fusion in ACDF, a comparison between autograft, allograft, and synthetic cagesQuantifying cervical cord deformation with automated MRI: validation and clinical correlates in degenerative cervical myelopathyThe impact of estrogen replacement therapy on revision rates and outcomes after anterior cervical discectomy and fusion: a propensity-matched cohort studyImaging biomarkers derived using artificial intelligence pipeline–enhanced prognostication of patients undergoing surgery for nontraumatic spinal cord injury due to degenerative cervical myelopathyWhat patients expect and what they experience: symptom-specific expectation fulfillment and functional recovery in degenerative cervical myelopathy. A retrospective analysis of prospectively collected data from the multicentre Canadian Surgical Spine RegistryBiomechanical comparison of 7 occipital–cervical fixation constructs using finite element analysisOutpatient anterior cervical decompression and fusion: a survey of Canadian surgeonsNational trends in surgical approach for degenerative cervical myelopathy and associated inpatient costsVariability of mechanism of mechanical complications between low-thoracic to pelvis and lumbar to pelvis fusions accurately predicted by musculoskeletal analysisOutcomes of circumferential minimally invasive technique versus open technique in adult spinal deformity surgery patients over 80 years of age: aCanadian Journal of Surgery · 2026
3. Pain attenuation during task: a proof-of-concept study for a new scoring metric to capture individual differences in chronic pain changes by task engagementFrontiers in Pain Research · 2026
4. Culturally adapted psychoeducation for bipolar disorder: a multicentre, assessor-masked, randomised controlled trialEClinicalMedicine · 2026
5. Preoperative Functional Imaging Predicts Deep Brain Stimulation Outcome in Craniocervical DystoniaMovement Disorders · 2026
6. Defining the Clinical Phenotypic Ground Truth: Expert Interrater Agreement in Hyperkinetic Movement DisordersMovement Disorders Clinical Practice · 2026
7. A Computational Framework for Myelin as a Regulator of Temporal Integration, Neuronal Excitability, and Synaptic PlasticityGlia · 2026
8. Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding siteNature Communications · 2026
9. Unified long-read panel for Parkinson’s and repeat expansion disordersnpj Parkinson s Disease · 2026
10. Should Paratonia Be Considered a Movement Disorder? Implications for Clinical ManagementMovement Disorders Clinical Practice · 2026
11. Head-only MRI of deep brain stimulation devices at 0.5 T: Patient-derived approaches for estimating radiofrequency heatingNeuroImage · 2026
12. Optimized Brain Functional MRI for Patients With Deep Brain Stimulation SystemsNeurosurgery · 2026
13. Groaning in Progressive Supranuclear Palsy: Insights From a Large Asian CohortMovement Disorders Clinical Practice · 2026
14. Practice Patterns Related to Neuromodulation and Continuous Subcutaneous Infusion of Foslevodopa/Foscarbidopa Infusion: A Survey of PSG MembersMovement Disorders · 2026
15. fMRI during active GPi DBS uncovers target-specific networksnpj Parkinson s Disease · 2026
16. Authors’ Comments on “Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation”Movement Disorders · 2026
17. SEMA6B ‐Related Progressive Myoclonic Epilepsy Mimicking Angelman SyndromeMovement Disorders Clinical Practice · 2026
18. Phenotypic Exploration in Patients with Heterozygous Variant in AFG3L2 Gene: A Case‐Series and Literature ReviewMovement Disorders Clinical Practice · 2026
19. Homogenous Cell Transplantation Trials in Parkinson's Disease: A Systematic Review and Meta‐AnalysisMovement Disorders Clinical Practice · 2026
20. The pattern of fMRI activation with STN DBS reveals symptom-specific networksnpj Parkinson s Disease · 2026