Vertex Pharmaceuticals (United Kingdom)

Recent papers from Vertex Pharmaceuticals (United Kingdom)

1. Development of a One‐Pot Borylation/Suzuki Cross‐Coupling Using Tetrahydroxydiboron en Route to RemibrutinibEuropean Journal of Organic Chemistry · 2026
2. N ‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary SulfonimidamidesAngewandte Chemie · 2026
3. N ‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary SulfonimidamidesAngewandte Chemie International Edition · 2026
4. Cryo-EM structure of the human Kir7.1 channel reveals the molecular basis of snowflake vitreoretinal degeneration diseaseCommunications Biology · 2026
5. Abstract 470: JZP898, a conditionally activated interferon alpha, generates efficacy and robust TME engagement in syngeneic mouse models.Cancer Research · 2026
6. Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?Journal of Medicinal Chemistry · 2025
7. Multi-laboratory comparisons of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practicesScientific Reports · 2025
8. Divergent contiguous stereocenters via asymmetric conjugate additions to cycloalkenyl ketonesChem Catalysis · 2025
9. Total Synthesis and Structure Determination of Mycapolyol E Using Iterative Homologation of Boronic EstersAngewandte Chemie Novit · 2025
10. LONGITUDE: An observational study of the long-term effectiveness of elexacaftor/tezacaftor/ivacaftor in people aged ≥12 years with cystic fibrosis using data from the United Kingdom Cystic Fibrosis Registry - 2-year analysisJournal of Cystic Fibrosis · 2025
11. Essential and dual effects of Notch activity on a natural transdifferentiation eventNature Communications · 2025
12. A cross-species assessment of in silico prediction methods of steady-state volume of distribution using Simcyp simulatorsJournal of Pharmaceutical Sciences · 2024
13. Challenges of Absolute Binding Free Energies for Membrane Exposed Binding Pockets2024
14. Real-world impact of ivacaftor in people with cystic fibrosis and select ivacaftor-responsive mutationsBMJ Open Respiratory Research · 2024
15. Enantioselective Synthesis of Sealutomicin CJournal of the American Chemical Society · 2024
16. Some Items of Interest to Process R&D Chemists and EngineersOrganic Process Research & Development · 2024
17. Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoproteins2024
18. Some Items of Interest to Process R&D Chemists and EngineersOrganic Process Research & Development · 2024
19. Enantioselective synthesis of sealutomicin C2024
20. Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoproteinsRSC Chemical Biology · 2024