Lead Discovery Center (Germany)

Recent papers from Lead Discovery Center (Germany)

1. Reducing PI4KIIIα Levels or Activity Limits Tau Seed Internalization and Assembly in Human Cortical NeuronsCells · 2026
2. Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1Cell Death and Disease · 2026
3. Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SARJournal of Medicinal Chemistry · 2026
4. Accelerating industrial vision: Systematic robot-assisted dataset preparation for object detection and pose estimationEngineering Applications of Artificial Intelligence · 2026
5. Lessons from Structural Biology for Understanding Drug Resistance in Gastrointestinal Stromal Tumors (GIST)Journal of Medicinal Chemistry · 2026
6. Pyrazolylpyrimidinamines Decorated via Petasis Reaction as Small-Molecule Activators of the RNA-Degrading Ribonuclease IRE1αACS Bio & Med Chem Au · 2026
7. An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α-Hemolysin by Blocking the Pullout of Its Stem Domain.2026
8. Towards selective peptide deformylase inhibitors: A mass spectrometry-based evaluation of in cellulo activity of actinonin and bromoindole derivativesEuropean Journal of Medicinal Chemistry · 2026
9. Covalent modification of a glutamic acid inspired by HaloTag technologyNature Communications · 2026
10. Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras SignalingJournal of Medicinal Chemistry · 2026
11. Direct-to-Biology Enabled Molecular Glue DiscoveryJournal of the American Chemical Society · 2025
12. Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A12025
13. Glucose Metabolism Controls Oxidative Burst and Lipid Mediator Production in Neutrophils upon Microbial ChallengemicroLife · 2025
14. Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and DegradersAngewandte Chemie International Edition · 2025
15. A highly efficient access to new antibacterial actinonin derivatives via Ugi four-component reaction2025
16. Enabling antibiotic research: towards selective peptide deformylase inhibitors2025
17. P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsyBritish Journal of Pharmacology · 2025
18. Phase II Trial of Ponatinib in Patients with Metastatic Gastrointestinal Stromal Tumor following Failure or Intolerance of Prior Therapy with Imatinib (POETIG Trial)Clinical Cancer Research · 2025
19. How to Facilitate Seamless Translation from Basic Concepts to New Heart Failure Drugs. A Scientific Statement of the Heart Failure Association of the ESCEuropean Journal of Heart Failure · 2025
20. Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R InhibitorsMolecules · 2025