MRC Integrative Epidemiology Unit

Recent papers from MRC Integrative Epidemiology Unit

1. Exploring the causal role of the human gut microbiome in breast cancer riskWellcome Open Research · 2026
2. Exploring the Causal Relationship Between Body Mass Index and Kidney Function: Tissue-Partitioned Mendelian RandomizationGenes · 2026
3. Adjusting for Medication Use in GWAS and Its Impact on Mendelian Randomisation Analyses: An Example of Systolic Blood Pressure in UK BiobankGenetic Epidemiology · 2026
4. PREGnancy, HEART Health and Cardiovascular Disease (PREG-HEART): protocol for a national, direct-to-participant prospective cohort studyBMJ Open · 2026
5. Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestriesNature Human Behaviour · 2026
6. Risk of orofacial clefts in offspring following maternal exposure to anti-seizure medications in a UK CPRD GOLD observational studyScientific Reports · 2026
7. Lactose and sucrose each stimulate hepatic de novo lipogenesis: A randomized crossover trialAmerican Journal of Clinical Nutrition · 2026
8. The Hospital Burden of Chronic Kidney Disease in Ireland: A National Analysis of Healthcare Utilisation, Mortality and CostsBMC Health Services Research · 2026
9. Estimating direct and indirect genetic effects on emerging variation in depressive symptoms in early adolescence: a trio polygenic score analysis in the MoBa cohortEuropean Child & Adolescent Psychiatry · 2026
10. A flexible Monte Carlo quantitative bias analysis for unmeasured confoundingStatistical Methods in Medical Research · 2026
11. The Reported Prevalence of Micronutrient Deficiency after Metabolic Bariatric Surgery and Adherence to British Obesity and Metabolic Specialist Society Nutritional Guidelines: A Multicentre Retrospective Cohort StudyObesity Surgery · 2026
12. Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypesNature Mental Health · 2026
13. The association between adverse experiences throughout the life-course and risk of dementia in the English Longitudinal Study of AgeingJournal of Alzheimer s Disease · 2026
14. Depression and anxiety as causes and consequences of urinary incontinence in women: a population-based study2026
15. Association of Assisted Reproductive Technologies with offspring cord blood DNA methylation across cohorts.2020
16. The effect of genetically proxied IL-6 signalling on severe malaria: A Mendelian randomisation analysis2022
17. Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsitesNature Communications · 2025
18. Use of dual-energy X-ray absorptiometry to evaluate variation in bone shape and alignment associated with radiographic knee osteoarthritis: Findings from a study of 19,053 individuals in UK BiobankOsteoarthritis and Cartilage Open · 2025
19. Role of anakinra in the management of children with severe dengueArchives of Disease in Childhood · 2025
20. Investigating the Relationship Between Maternal Smoking During Pregnancy and Offspring Handedness: Extending the Proxy Gene-by-Environment Mendelian Randomization Study Design to Include Polygenic Risk ScoresBehavior Genetics · 2025