Galapagos (Netherlands)

Recent papers from Galapagos (Netherlands)

1. Reversing detrimental effects of OA-related terminal maturation in high-throughput in vitro and biomimetic ex vivo human modelsArthritis Research & Therapy · 2026
2. Adamts5 deletion exacerbates inflammation and fibrosis resulting in compromised skeletal muscle regenerationAJP Cell Physiology · 2026
3. Selective SIK2/SIK3 inhibition reprograms pro- and antiinflammatory pathways in myeloid cells, improving autoimmune disease outcomesJCI Insight · 2026
4. NEO-STIM advances personalized neoantigen-specific adoptive T cell therapyNature Communications · 2026
5. Leveraging metabolic similarity in a 1H NMR database of medicinal plants to advance pharmacognostic insightsScientific Reports · 2026
6. A phenotype-driven data and drug repurposing strategy used to identify potential treatments targeting chondrocyte hypertrophy in osteoarthritisBiomedicine & Pharmacotherapy · 2025
7. Randomized clinical efficacy and safety study of peltopepimut-S plus cemiplimab compared to cemiplimab alone in patients with recurrent/metastatic HPV16-positive head and neck cancerJournal for ImmunoTherapy of Cancer · 2025
8. Structure–Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 InhibitorJournal of Medicinal Chemistry · 2025
9. Development and validation of a predictive 6-min walk score in patients with idiopathic pulmonary fibrosisEuropean Respiratory Journal · 2025
10. ADAMTS-5 inhibition reduces muscle inflammation and fibrosis and improves function in mouse models of Duchenne muscular dystrophyScience Translational Medicine · 2025
11. Factors associated with response to filgotinib and the prognostic power of faecal calprotectin for ulcerative colitis in the phase 2b/3 SELECTION trialDigestive and Liver Disease · 2025
12. A phase 1 trial of fully human BCMA CAR-T therapy for relapsed/refractory multiple myeloma with 5-year follow-upBlood · 2025
13. Mathematical analysis of long‐distance polar auxin transport data of pin mutants questions the role of PIN1 as postulated in the chemi‐osmotic theoryPhysiologia Plantarum · 2025
14. Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension studyRMD Open · 2025
15. Mediators of Filgotinib Treatment Effects in Ulcerative Colitis: Exploring Circulating Biomarkers in the Phase 2b/3 SELECTION StudyInflammatory Bowel Diseases · 2024
16. Distinct trajectories of symptomatic response in ulcerative colitis during filgotinib therapy: A post hoc analysis from the SELECTION studyUnited European Gastroenterology Journal · 2024
17. Benefit-Risk Trade-offs and Patient Preferences for Therapy Selection in Ulcerative Colitis: a Multicountry Preference StudyInflammatory Bowel Diseases · 2024
18. Long‐term safety and efficacy of filgotinib for the treatment of moderately to severely active ulcerative colitis: Interim analysis from up to 4 years of follow‐up in the SELECTION open‐label long‐term extension studyAlimentary Pharmacology & Therapeutics · 2024
19. Filgotinib in Active Noninfectious UveitisJAMA Ophthalmology · 2024
20. Prediction of Disease Progression and Clinical Response in Systemic Sclerosis: Experience From a Proof‐of‐Concept TrialACR Open Rheumatology · 2024