Kymab (United Kingdom)

Recent papers from Kymab (United Kingdom)

1. Membrane protein solubilization and structure determination using de novo–designed proteinsScience · 2026
2. Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protectionImmunity · 2026
3. First-in-human, phase 1, open-label study of alomfilimab, an anti-ICOS antibody, as a single agent and in combination with anti-PD-L1 in advanced malignanciesJournal for ImmunoTherapy of Cancer · 2026
4. Intranasal delivery of mRNA expressing newly identified Acinetobacter baumannii antigens protects against bacterial lung diseasenpj Vaccines · 2025
5. A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike proteinCell Reports · 2025
6. Solubilization of Membrane Proteins using designed protein WRAPS2025
7. The genetic architecture of HIV-1 virulenceVirus Evolution · 2025
8. Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogensnpj Vaccines · 2024
9. A transgenic mouse with a humanised B cell repertoire mounts an antibody response to influenza infection and vaccinationThe Journal of Infectious Diseases · 2024
10. Exploiting human immune repertoire transgenic mice for protective monoclonal antibodies against antimicrobial resistant Acinetobacter baumanniiNature Communications · 2024
11. Detection of M. tuberculosis DNA in peripheral blood mononuclear cells of tuberculosis contacts does not associate with blood RNA signatures for incipient tuberculosisEuropean Respiratory Journal · 2024
12. Toward a molecular microbial blood test for tuberculosis infectionInternational Journal of Infectious Diseases · 2024
13. Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice2024
14. A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic miceBlood Advances · 2024
15. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite proteinCell Reports · 2023
16. Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancerBiological Chemistry · 2023
17. Detection of M. tuberculosis DNA in TB contacts’ PBMC does not associate with blood RNA signatures for incipient tuberculosis2023
18. Safety and efficacy of amlitelimab, a fully human nondepleting, noncytotoxic anti-OX40 ligand monoclonal antibody, in atopic dermatitis: results of a phase IIa randomized placebo-controlled trialBritish Journal of Dermatology · 2023
19. Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria modelnpj Vaccines · 2023
20. Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencingeLife · 2023