PsiOxus Therapeutics (United Kingdom)

Recent papers from PsiOxus Therapeutics (United Kingdom)

1. TANGENT study design: a phase III, randomized study of emactuzumab for the treatment of tenosynovial giant cell tumorsFuture Oncology · 2026
2. RAISIC-1: A phase 1/2 clinical trial of the GPR65 inhibitor PTT-4256—Preliminary safety, tolerability, pharmacokinetic, and pharmacodynamic results.Journal of Clinical Oncology · 2026
3. A Langendorff-heart discovery pipeline demonstrates cardiomyocyte targeting by extracellular vesicles functionalized with beta-blockers using click-chemistryJournal of Molecular and Cellular Cardiology · 2025
4. Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editorsNature Communications · 2025
5. The Inflammatory Landscape of a Whole‐Tissue Explant Model of Hidradenitis SuppurativaExperimental Dermatology · 2025
6. Antibody-displaying extracellular vesicles for targeted cancer therapyNature Biomedical Engineering · 2024
7. Oxidative stress‐induced changes in the transcriptomic profile of extracellular vesiclesJournal of Extracellular Biology · 2024
8. TRPC3 signalling contributes to the biogenesis of extracellular vesiclesJournal of Extracellular Biology · 2023
9. Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypesBrain · 2023
10. Infrared Multiphoton Dissociation Enables Top‐Down Characterization of Membrane Protein Complexes and G Protein‐Coupled ReceptorsAngewandte Chemie International Edition · 2023
11. Infrared Multiphoton Dissociation Enables Top‐Down Characterization of Membrane Protein Complexes and G Protein‐Coupled ReceptorsAngewandte Chemie · 2023
12. Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles2023
13. Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery2023
14. Surface display of functional moieties on extracellular vesicles using lipid anchorsJournal of Controlled Release · 2023
15. Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles2023
16. A compendium of single extracellular vesicle flow cytometryJournal of Extracellular Vesicles · 2023
17. Cell‐specific targeting of extracellular vesicles through engineering the glycocalyxJournal of Extracellular Vesicles · 2022
18. Quantitative polymerase chain reaction in the bioanalytical laboratory and technical and scientific considerations for nonclinical and clinical assay characterization, validation and sample analysisBioanalysis · 2022
19. Mouse and cellular models of KPTN -related disorder implicate mTOR signalling in cognitive and progressive overgrowth phenotypes2022
20. Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse modelsJournal of Extracellular Vesicles · 2022