Phenex Pharmaceuticals (Germany)

Recent papers from Phenex Pharmaceuticals (Germany)

1. Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of PsoriasisJournal of Medicinal Chemistry · 2025
2. Development of Cilofexor, an Intestinally-Biased Farnesoid X Receptor Agonist, for the Treatment of Fatty Liver DiseaseJournal of Pharmacology and Experimental Therapeutics · 2024
3. Positive allosteric γ‐aminobutyric acid type A receptor modulation prevents lipotoxicity‐induced injury in hepatocytes in vitroDiabetes Obesity and Metabolism · 2022
4. Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534Scientific Reports · 2021
5. Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 ActivationKidney360 · 2021
6. Regulation of IL-22BP in psoriasisSHILAP Revista de lepidopterología · 2018
7. A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatmentCell Death and Differentiation · 2018
8. The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunctionJournal of Hepatology · 2016
9. Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritisScientific Reports · 2016
10. RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345Expert Opinion on Therapeutic Patents · 2016
11. Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue UptakeBioconjugate Chemistry · 2016
12. MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastomaOncotarget · 2016
13. Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosisOncotarget · 2016
14. Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742Expert Opinion on Therapeutic Patents · 2016
15. On the Pharmacology of Farnesoid X Receptor Agonists: Give me an “A”, Like in “Acid”Nuclear Receptor Research · 2016
16. Reprogramming of the ERRα and ERα Target Gene Landscape Triggers Tamoxifen Resistance in Breast CancerCancer Research · 2015
17. The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine‐rich glycoproteinInternational Journal of Cancer · 2014
18. Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegenerationBMC Neuroscience · 2013
19. IgE knock‐in mice suggest a role for high levels of IgE in basophil‐mediated active systemic anaphylaxisEuropean Journal of Immunology · 2013
20. Mechanism of the Tissue-Specific Action of the Selective Androgen Receptor Modulator S-101479Biological and Pharmaceutical Bulletin · 2013