Cibles Thérapeutiques et conception de médicaments

Recent papers from Cibles Thérapeutiques et conception de médicaments

1. Revisit of the admitted control RND efflux pumps’ inhibitor PAβN: use limitations, and structural revelation in complex with MexBFrontiers in Pharmacology · 2026
2. Dual-stage inhibition of Plasmodium falciparum by a Skeletocutis derived fungal metabolite targeting Pyruvate Kinase II2026
3. Population pharmacokinetics of encorafenib and binimetinib in real-world patients with BRAFV600E/K-mutant metastatic melanomaCancer Chemotherapy and Pharmacology · 2026
4. Access to Natural and Unnatural 28-Norlupane Endoperoxides by Isayama–Mukaiyama Cobalt-Catalyzed Hydroperoxyl Silylation and Evaluation of Antiplasmodial ActivityJournal of Natural Products · 2026
5. Allium ursinum L. from the apennine flora: a phytoalimurgic resource for modulating gut inflammationRSC Advances · 2026
6. CFTR correctors potentiate gating mutants causing cystic fibrosisJournal of Cystic Fibrosis · 2025
7. Synthesis of Chromeno[2,3‐c]Pyrazol‐(2 H )‐one Derivatives: A New Class of Antibacterial and Antifungal AgentsChemistry & Biodiversity · 2025
8. Comparison of rituximab induction and maintenance regimens in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: PK/PD modelling of ANCA and gammaglobulin levels in real-world patientsEBioMedicine · 2025
9. Urea intermediates as key gateways to 4-amino-1,5-dihydro-2H-chromeno[2,3-d]pyrimidin-2-one scaffolds: Synthetic streamlining and structural diversificationTetrahedron · 2025
10. LC-MS/MS method for quantification of avacopan in human plasma from patients treated for antineutrophil cytoplasmic antibody-associated vasculitisJournal of Pharmaceutical and Biomedical Analysis · 2025
11. Machine learning analysis of molecular dynamics properties influencing drug solubilityScientific Reports · 2025
12. Access to Unnatural Enantioenriched Amino Acids Derived from Phenylglycine through Nickel-Catalyzed Suzuki–Miyaura Coupling Involving Carbon–Oxygen Bond InsertionThe Journal of Organic Chemistry · 2025
13. Identification of New Key Players for Ferrous Iron Export in the Asymmetric Inner Gate of Human Ferroportin 1The FASEB Journal · 2025
14. Synthetic approach to a novel quinoline scaffold 4-amino-5,10-dihydropyrimido[4,5-b]quinolin-2(1H)-one with antiproliferative effects on HCT116 colon cancer cell linesJournal of Molecular Structure · 2025
15. Antinociceptive and anti-inflammatory effects of essential oil from Lippia thymoides MART. & SCHAUER (VERBENACEAE)Natural Product Research · 2025
16. Targeted Dereplication of H. patulum and H. hookeranium Extracts: Establishing MS/MS Fingerprints for the Identification of Polycyclic Polyprenylated AcylphloroglucinolsMolecules · 2025
17. Translating community-wide spectral library into actionable chemical knowledge: a proof of concept with monoterpene indole alkaloidsSocio-Environmental Systems Modeling · 2025
18. Illuminating the Path of Rearrangement: Visible Light‐Driven Pd‐Catalyzed Substituted Olefins SynthesisAdvanced Synthesis & Catalysis · 2025
19. Exposure–response relationship of niraparib in maintenance therapy for recurrent ovarian cancer: ancillary analysis of the French GINECO–NiQoLe studyESMO Open · 2025
20. Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the risks to human health associated with the proliferation of Ostreopsis spp. on the Basque coastFood Risk Assess Europe · 2025