Flagship Pioneering (United States)

Recent papers from Flagship Pioneering (United States)

1. Triple-Frequency Electromagnetic Stimulation Combined with Fingolimod Reduces Breast Cancer Cell Proliferation and Metastasis-Associated Extracellular Vesicle Protein LevelsPharmaceuticals · 2026
2. Development and Validation of a Multimodal-Multitask Deep Learning Approach for Estimating Late Distant Recurrence Risk in HR–Positive Early Breast CancerCancer Research Communications · 2026
3. 25 years of applying the 3Rs principles in safety pharmacology: success stories and future perspectivesFrontiers in Physiology · 2026
4. Transcriptomic and metabolite-centric profiling reveal aryl hydrocarbon receptor-mediated cytochrome P450 1A1 autoinduction of the selective modulator PM-4321Drug Metabolism and Disposition · 2026
5. Somatic genomics as a discovery engine for biomedicineCell · 2026
6. A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitabilityNature Communications · 2026
7. Physiological foundation modeling for subclinical disease assessment: a prospective pilotJAMIA Open · 2026
8. Reinforced molecular dynamics: Physics-infused generative machine learning model simulates protein motionPNAS Nexus · 2026
9. A neuron type-specific microexon in Ank3 /ankyrin-G modulates calcium activity and neuronal excitability2025
10. Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers2025
11. A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in miceScience Immunology · 2025
12. Target‐Mediated Drug Disposition (TMDD) Revisited: High Versus Low‐Affinity Approximations of the TMDD ModelCPT Pharmacometrics & Systems Pharmacology · 2025
13. Image guided construction of a common coordinate framework for spatial transcriptome dataScientific Reports · 2025
14. Platform-dependent effects of genetic variants on plasma APOL12025
15. Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation eventsScientific Reports · 2025
16. BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosisNature Communications · 2024
17. Colocalization of Cancer-Associated Biomarkers on Single Extracellular Vesicles for Early Detection of CancerJournal of Molecular Diagnostics · 2024
18. Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosisScientific Reports · 2024
19. Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma modelsNature Communications · 2024
20. Critical reagent considerations for immunogenicity assay development for bispecific biotherapeutic candidatesBioanalysis · 2024