Plex Pharmaceuticals (United States)

Recent papers from Plex Pharmaceuticals (United States)

1. Abstract CT139: Germline HFE mutations predict for durable response to arginine depletion with pegargiminase-based chemotherapy in pleural mesotheliomaCancer Research · 2026
2. Discovery and Structural Optimization of BRD4-Selective Monovalent Direct DegradersACS Medicinal Chemistry Letters · 2026
3. Abstract 7074: PLX-61639, a potent and orally bioavailable SMARCA2-selective monovalent direct degrader, enhances efficacy of standard of care agents in SMARCA4 mutant tumor models.Cancer Research · 2026
4. Abstract 4600: Discovery of PLX-66140, a first-in-class, potent and selective CDK2 molecular glue degrader for CCNE1-amplified tumorsCancer Research · 2026
5. Chronic convection-enhanced delivery of MTX110 into the brainstem for pediatric diffuse midline glioma, phase I trialNeuro-Oncology Pediatrics · 2026
6. Argon fluoride laser system for high gain direct drive fusionOptics Express · 2025
7. BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced ApoptosisClinical Cancer Research · 2025
8. Acute Myeloid Leukemia with deletion 5q is an epigenetically distinct subgroup defined by heterozygous loss of KDM3B2024
9. Abstract CT066: Phase 1 study of MDM2 antagonist ASTX295 in patients with solid tumors with wild-type TP53Cancer Research · 2024
10. Guadecitabine vs TC in relapsed/refractory AML after intensive chemotherapy: a randomized phase 3 ASTRAL-2 trialBlood Advances · 2024
11. Guadecitabine vs treatment choice in newly diagnosed acute myeloid leukemia: a global phase 3 randomized studyBlood Advances · 2023
12. Pharmacokinetics and repeated dose 28‐day oral toxicity studies of acetaminophen nanosuspensionJournal of Biomedical Materials Research Part B Applied Biomaterials · 2023
13. Dose‐escalation trial of combination dabrafenib, trametinib, and AT13387 in patients with BRAF‐mutant solid tumorsCancer · 2023
14. Phase I Trial of a Therapeutic DNA Vaccine for Preventing Hepatocellular Carcinoma from Chronic Hepatitis C Virus (HCV) InfectionCancer Prevention Research · 2022
15. Role and Complication of Existing and Newer Calcium Channel Blockers in Hypertension TreatmentJournal of Pharmaceutical Research International · 2022
16. Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsyGlia · 2022
17. A validated liquid chromatography‐tandem mass spectroscopy method for the quantification of tolinapant in human plasmaAnalytical Science Advances · 2022
18. Genomic catastrophe, the peritoneal cavity and ovarian cancer preventionThe Journal of Pathology · 2022
19. Population Pharmacokinetics of Melphalan for Pediatric Patients Undergoing Hematopoietic Cell TransplantationThe Journal of Clinical Pharmacology · 2022
20. Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolismBioFactors · 2021