Aileron (United States)

Recent papers from Aileron (United States)

1. A first-in-pediatric study of ALRN-6924, a novel stapled-peptide dual MDM2/MDMX inhibitor, for children with advanced hematologic and solid malignanciesClinical Cancer Research · 2026
2. Transient p53/p21 activation selectively protects healthy human hair follicles and their stem cells from chemotherapy.2026
3. Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical DevelopmentJournal of Medicinal Chemistry · 2023
4. First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer modelsBreast Cancer Research · 2021
5. MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastomaScientific Reports · 2021
6. Solving the Competitive Binding Equilibria between Many Ligands: Application to High-Throughput Screening and Affinity OptimizationAnalytical Chemistry · 2020
7. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical modelsNature Communications · 2018
8. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemiaScience Translational Medicine · 2018
9. Hydrogen Exchange-Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic PropertiesAnalytical Chemistry · 2013
10. Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapyProceedings of the National Academy of Sciences · 2013
11. d-Amino Acid Oxidase Activity Is Inhibited by an Interaction with Bassoon Protein at the Presynaptic Active ZoneJournal of Biological Chemistry · 2011
12. Molecular mechanisms of drug resistance in tyrosine kinases cAbl and cKitCritical Reviews in Biochemistry and Molecular Biology · 2011
13. Biomarkers in Drug Development: A Handbook of Practice, Application and StrategyBritish Journal of Clinical Pharmacology · 2010
14. Probing the α‐Helical Structural Stability of Stapled p53 Peptides: Molecular Dynamics Simulations and AnalysisChemical Biology & Drug Design · 2010
15. Inhibitors of the Lipid Phosphatase SHIP2 Discovered by High Throughput Affinity Selection-Mass Spectrometry Screening of Combinatorial LibrariesCombinatorial Chemistry & High Throughput Screening · 2009