Domainex (United Kingdom)

Recent papers from Domainex (United Kingdom)

1. Soil health assessment using buried cotton underpants with the help of 1000 citizen scientistsPlants People Planet · 2026
2. A GCN1-independent activator of the kinase GCN22025
3. Structural molecular details of the endocytic adaptor protein CALM upon binding with phosphatidylinositol 4,5-bisphosphate-containing model membranesCommunications Chemistry · 2025
4. A GCN1-independent activator of the kinase GCN2eLife · 2025
5. The Sensitivity of HIV-1 gp120 Polymorphs to Inhibition by Temsavir Correlates to Temsavir Binding On-rateAntiviral Research · 2024
6. The Novel DNA Binding Mechanism of Ridinilazole, a Precision Clostridiodes difficile AntibioticAntimicrobial Agents and Chemotherapy · 2023
7. Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic ImplicationsPharmaceuticals · 2023
8. Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane traffickingActa Neuropathologica Communications · 2023
9. Differential Effects of Mutations of Popeye Domain Containing Proteins on Heteromeric Interaction and Membrane Trafficking2022
10. Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibitionProceedings of the National Academy of Sciences · 2022
11. Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R MutantBiomolecules · 2022
12. Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant2022
13. Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancerScience Translational Medicine · 2021
14. Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?Basic Research in Cardiology · 2021
15. IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signallingJournal of Cellular and Molecular Medicine · 2020
16. Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4Scientific Reports · 2020
17. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death2020
18. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In VivoCell stem cell · 2019
19. Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite AllergensInternational Journal of Molecular Sciences · 2018
20. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragmentNature Communications · 2018