Isomerase Therapeutics (United Kingdom)

Recent papers from Isomerase Therapeutics (United Kingdom)

1. The succinate prodrug NV354 prevents brain lesions and late-stage motor dysfunction in mitochondrial complex I deficiencyiScience · 2026
2. Mutasynthesis of C17- and C21-Substituted Ansamitocins for Use as ADC PayloadsACS Omega · 2025
3. Engineering the TCA cycle regulator GarA to increase erythromycin production in Saccharopolyspora erythraeaMicrobiology · 2025
4. Development and In Vitro Characterization of Milk-Derived Extracellular Vesicle-Mithramycin Formulations for Potential Glioma TherapyMolecular Pharmaceutics · 2025
5. Glucose-1-phosphate thymidylyltransferase promotes the production of 3- O -α-mycarosylerythronolide B in Streptomyces coelicolorJournal of Applied Microbiology · 2024
6. Conditional language models enable the efficient design of proficient enzymes2024
7. Heterologous Expression of the Formicamycin Biosynthetic Gene Cluster Unveils Glycosylated Fasamycin CongenersJournal of Natural Products · 2023
8. Novel Cyclophilin Inhibitor Decreases Cell Proliferation and Tumor Growth in Models of Hepatocellular CarcinomaCancers · 2021
9. SodeclACM Transactions on Mathematical Software · 2020
10. Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2)Access Microbiology · 2020
11. Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver FibrosisCells · 2019
12. SODECL: An Open Source Library for Calculating Multiple Orbits of a System of Stochastic Differential Equations in Parallel2019
13. Driving the expression of the Salmonella enterica sv Typhimurium flagellum using flhDC from Escherichia coli results in key regulatory and cellular differencesScientific Reports · 2018
14. Diversity oriented biosynthesis via accelerated evolution of modular gene clustersNature Communications · 2017
15. A global map of saltmarshesZooKeys · 2017
16. Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiencyNature Communications · 2016
17. An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35Applied and Environmental Microbiology · 2016
18. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitorScientific Reports · 2015
19. Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferaseChemical Science · 2015
20. Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivoProceedings of the National Academy of Sciences · 2014