LinXis Biopharmaceuticals (Netherlands)

Recent papers from LinXis Biopharmaceuticals (Netherlands)

1. PDGFRβ-Targeting VHH Tracer Enables Noninvasive PET Imaging of Kidney FibrosisJournal of Nuclear Medicine · 2026
2. Abstract Number: Esoc2026a1328 Tgd001, a Novel VWF-Targeting Thrombolytic, Effectively Degrades Ex-Vivo Human Stroke Thrombi and Demonstrates Safety and Activity in a Phase 1 Healthy Volunteer TrialEuropean Stroke Journal · 2026
3. Preclinical targeting of liver fibrosis with a 89Zr-labeled Fibrobody® directed against platelet derived growth factor receptor-βEuropean Journal of Nuclear Medicine and Molecular Imaging · 2024
4. Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in miceJHEP Reports · 2023
5. The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cellsPLoS ONE · 2023
6. Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in miceTheranostics · 2021
7. An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtIILinkerLxfor Improved Manufacturability of Antibody–Drug ConjugatesAngewandte Chemie · 2020
8. An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt II Linker Lx for Improved Manufacturability of Antibody–Drug ConjugatesAngewandte Chemie International Edition · 2020
9. A successful search for new, efficient, and silver-free manufacturing processes for key platinum( ii ) intermediates applied in antibody–drug conjugate (ADC) productionGreen Chemistry · 2020
10. Polymeric Micelles Employing Platinum(II) Linker for the Delivery of the Kinase Inhibitor DactolisibParticle & Particle Systems Characterization · 2019
11. First platinum(II)-based metal-organic linker technology (Lx®) for a plug-and-play development of antibody-drug conjugates (ADCs)Expert Opinion on Drug Delivery · 2019
12. The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitorJournal of Controlled Release · 2019
13. Folate-dactolisib conjugates for targeting tubular cells in polycystic kidneysJournal of Controlled Release · 2018
14. In Vivo Characterization of Platinum(II)-Based Linker Technology for the Development of Antibody–Drug Conjugates: Taking Advantage of Dual Labeling with 195mPt and 89ZrJournal of Nuclear Medicine · 2018
15. A Novel Platinum(II)–Based Bifunctional ADC Linker Benchmarked Using 89Zr-Desferal and Auristatin F–Conjugated TrastuzumabCancer Research · 2016
16. Platinum(II) as Bifunctional Linker in Antibody–Drug Conjugate Formation: Coupling of a 4‐Nitrobenzo‐2‐oxa‐1,3‐diazole Fluorophore to Trastuzumab as a ModelChemMedChem · 2015
17. Epac-Rap Signaling Reduces Oxidative Stress in the Tubular EpitheliumJournal of the American Society of Nephrology · 2014
18. Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infectionAIDS · 2003