Abstract Background Cognitive impairments are common in lower-grade gliomas (grades 1–3), but treatment options are limited. Tele-cognitive rehabilitation offers a potential solution. We conducted an interim pilot study to assess the feasibility, satisfaction, and early efficacy of tele-cognitive rehabilitation. Methods We enrolled adults with stable LrGG (≥ 6 months post-treatment) who had subjective and objective cognitive impairments (1 SD below-average in ≥2 domains). Participants received three-months of individual Goal Management Training (GMT), app-based ReMind, or texting. Cognition and patient-reported outcome (PROs) were assessed at baseline (T1), post-intervention (T2), and 9-months post-baseline (T3). We assessed enrollment, adherence, and satisfaction. Adherence was defined as ≥80% of participants completing ≥80% of the protocol; satisfaction as ≥6/7 for GMT and texting, and ≥4/5 for ReMind on a self-report Likert question. We used ANOVA, reliable change indices, and qualitative analytics. Results Thirty-nine participants were eligible and thirty-three prospectively enrolled for study; an 85% enrollment (17-GMT, 8-ReMind, 8-texting; 46.8 median age, 64.8 months from diagnosis, 55% had astrocytoma, and 76% had prior radiotherapy). Eighty-two percent of GMT (adequate), 100% of texting (adequate), and 33% retraining, 50% for compensation of ReMind (inadequate) completed ≥80% of the protocol. GMT (mean-6.75/7) and ReMind (mean-4.5/5) satisfaction were adequate, and texting (mean-4.5/7) was inadequate. Working memory improved from T1-to-T2 (p=0.02, η²=0.32) in 26% of the GMT group. Conclusion GMT demonstrates adequate feasibility, satisfaction, and may yield improvements in working memory, while texting and ReMind had challenges in acceptability or feasibility. Telehealth GMT warrants further investigation in LrGG.
Weyer-Jamora et al. (Sat,) studied this question.