What type of study is this?

This is a In Vitro Study study.

August 17, 2025

Phytochemical Analysis and Bioactivity Evaluation of Phoenix dactylifera L. Ethanolic Extract and Cosmetic Cream: Antibacterial, Antioxidant, and Anti‐Inflammatory Properties

Key Points

Ethanolic extract of Ghars date seeds shows strong antioxidant effects, suggesting a valuable component for skincare.
The extract exhibited significant antimicrobial activity against Bacillus subtilis and Staphylococcus aureus, indicating its application in cosmetics.
Extraction yielded 11.425% ethanolic extract with high levels of flavonoids and phenolics, enhancing its effectiveness.
The study supports the use of natural ingredients from date seeds for developing effective healthcare and cosmetic products.

Abstract

ABSTRACT Phoenix dactylifera L. (Ghars variety) seeds, widely available in Algeria, represent a valuable natural resource. Their rich phytochemical composition presents promising potential for applications in health and skincare. This study evaluates the phytochemical profile and biological activities of ethanolic extracts (EE) from Ghars date seeds and assesses the antimicrobial efficacy of a formulated cosmetic cream. Ethanolic extraction yielded 11.425% EE. Phytochemical screening, total flavonoid content (TFC), and total phenolic content (TPC) were determined. Antioxidant activity was evaluated using ferric reducing antioxidant power (RAP) and DPPH assays. Anti‐inflammatory activity was assessed via membrane stabilization, and the antimicrobial potential of the EE‐based cream was tested against selected bacterial strains. The EE exhibited high flavonoid (68.81 mg/mL) and phenolic content (118.6 mg/mL). Antioxidant assays showed strong activity, with IC 50 values of 47.86 μg/mL (FRAP) and 35.85 μg/mL (DPPH). The extract demonstrated notable anti‐inflammatory effects. The EE‐based cream displayed significant antimicrobial activity, with inhibition zones up to 27 mm against Bacillus subtilis and marked effects against Staphylococcus aureus and Pseudomonas aeruginosa . Ghars date seed EE shows strong antioxidant, anti‐inflammatory, and antimicrobial properties, supporting its use as a natural ingredient in cosmetic and healthcare formulations.

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Cite This Study

Cherfi et al. (Sun,) studied this question.

synapsesocial.com/papers/68af453aad7bf08b1ead29ba https://doi.org/https://doi.org/10.1002/bmc.70199

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