Acne vulgaris, known in Unani medicine as Busoor-e-Labaniya, is a common chronic inflammatory disorder of the pilosebaceous unit, particularly affecting adolescents and young adults characterized by comedones, papules, pustules, and sometimes nodules. The condition has both physical and psychological impacts. In the Unani system, its pathology is understood through the lens of humoral imbalance, particularly the accumulation of Madda-e-Sadidiya (viscous morbid material) and is often linked to dietary, hormonal, and lifestyle factors. Classical Unani physicians such as Ibn Sina, Zakariya Razi and Azam Khan provided detailed descriptions of its etiology and treatment. Their approach includes systemic detoxification (Tanqiya-e-Badan), correction of temperament and the use of specific pharmacological agents like Mujaffif (Desiccants), Muhallil (Anti-inflammatory), Jali (Detergents), and Musaffi-e-Dam (Blood purifiers). Local applications in the form of Ubtan, Zimad, and Tila are commonly used to soothe inflammation, cleanse the skin, and lighten scars. In contrast to modern pharmacological treatments which can have adverse effects Unani therapies are traditionally considered safe, holistic, and cost-effective. The integration of historical insights and traditional practices with contemporary research offers promising directions for safe and sustainable acne management, though further scientific validation is essential. KEYWORDS: Acne vulgaris, Busoor-e-Labaniya, Unani medicine, Tanqiya-e-Mawad, Musaffi-e-Dam, Traditional medicine, Skin disorders. References 1. Kopaei R, Khajegir A, Kiani S, The Association between Dystemperament and Prevention of diseases: A Systemetic Review. J Clin Diagn Res. 2016 Sep;10(9):YE01-YE06. 2. Tahir MC. Review article pathogenesis of acne vulgaris: Simplified. J Pakistan Asso of Dermatol. 2010;20:93-94. 3. 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